Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.

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Autores principales:	Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S. Lee, Samuel J. Rodgers, Fuyi Li, Cheng Huang, Ralf B. Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K. Brown, Christina A. Mitchell, Kaylene J. Simpson, Roger J. Daly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16b94020768b4b0886330aa70dd0da0d
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spelling	oai:doaj.org-article:16b94020768b4b0886330aa70dd0da0d2021-12-02T16:58:17ZCharacterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation10.1038/s41467-018-08154-12041-1723https://doaj.org/article/16b94020768b4b0886330aa70dd0da0d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08154-1https://doaj.org/toc/2041-1723The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.Xiuquan MaLuxi ZhangJiangning SongElizabeth NguyenRachel S. LeeSamuel J. RodgersFuyi LiCheng HuangRalf B. SchittenhelmHoward ChanChanly ChheangJianmin WuKristin K. BrownChristina A. MitchellKaylene J. SimpsonRoger J. DalyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
description	The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.
format	article
author	Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly
author_facet	Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly
author_sort	Xiuquan Ma
title	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_short	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_full	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_fullStr	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_full_unstemmed	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_sort	characterization of the src-regulated kinome identifies sgk1 as a key mediator of src-induced transformation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/16b94020768b4b0886330aa70dd0da0d
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Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

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