Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing.
Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia. BCL11A has been identified as a key regulator of HbF silencing, although its precise mechanisms of action remain incompletely understood. Recent studies have identified pathogenic mut...
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Autores principales: | Yong Shen, Rick Li, Kristian Teichert, Kara E Montbleau, Jeffrey M Verboon, Richard A Voit, Vijay G Sankaran |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/16c4ace60f69490ea3d73aa1074950f0 |
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