Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession

Abstract Background Recently, we reported a novel neuroimaging technique, unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS), which uses a tailored 3D unbalanced steady-state free precession (3D uSSFP) acquisition to suppress the blood pool signal while minimizing bulk motion sensitivity. In t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Robert R. Edelman, Nondas Leloudas, Jianing Pang, Ioannis Koktzoglou
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	T1 relaxation-enhanced steady-state Unbalanced 3D steady-state free precession Breath-hold Navigator gating Electrocardiographic (ECG) gating Magnetic resonance Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/16c6438fa25a45be85c4568853f7667e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16c6438fa25a45be85c4568853f7667e
record_format	dspace
spelling	oai:doaj.org-article:16c6438fa25a45be85c4568853f7667e2021-11-07T12:21:52ZDark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession10.1186/s12968-021-00808-21532-429Xhttps://doaj.org/article/16c6438fa25a45be85c4568853f7667e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12968-021-00808-2https://doaj.org/toc/1532-429XAbstract Background Recently, we reported a novel neuroimaging technique, unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS), which uses a tailored 3D unbalanced steady-state free precession (3D uSSFP) acquisition to suppress the blood pool signal while minimizing bulk motion sensitivity. In the present work, we hypothesized that 3D uSSFP might also be useful for dark blood imaging of the chest. To test the feasibility of this approach, we performed a pilot study in healthy subjects and patients undergoing cardiovascular magnetic resonance (CMR). Main body The study was approved by the hospital institutional review board. Thirty-one adult subjects were imaged at 1.5 T, including 5 healthy adult subjects and 26 patients (44 to 86 years, 10 female) undergoing a clinically indicated CMR. Breath-holding was used in 29 subjects and navigator gating in 2 subjects. For breath-hold acquisitions, the 3D uSSFP pulse sequence used a high sampling bandwidth, asymmetric readout, and single-shot along the phase-encoding direction, while 3 shots were acquired for navigator-gated scans. To minimize signal dephasing from bulk motion, electrocardiographic (ECG) gating was used to synchronize the data acquisition to the diastolic phase of the cardiac cycle. To further reduce motion sensitivity, the moment of the dephasing gradient was set to one-fifth of the moment of the readout gradient. Image quality using 3D uSSFP was good-to-excellent in all subjects. The blood pool signal in the thoracic aorta was uniformly suppressed with sharp delineation of the aortic wall including two cases of ascending aortic aneurysm and two cases of aortic dissection. Compared with variable flip angle 3D turbo spin-echo, 3D uSSFP showed improved aortic wall sharpness. It was also more efficient, permitting the acquisition of 24 slices in each breath-hold versus 16 slices with 3D turbo spin-echo and a single slice with dual inversion 2D turbo spin-echo. In addition, lung and mediastinal lesions appeared highly conspicuous compared with the low blood pool signals within the heart and blood vessels. In two subjects, navigator-gated 3D uSSFP provided excellent delineation of cardiac morphology in double oblique multiplanar reformations. Conclusion In this pilot study, we have demonstrated the feasibility of using ECG-gated 3D uSSFP for dark blood imaging of the heart, great vessels, and lungs. Further study will be required to fully optimize the technique and to assess clinical utility.Robert R. EdelmanNondas LeloudasJianing PangIoannis KoktzoglouBMCarticleT1 relaxation-enhanced steady-stateUnbalanced 3D steady-state free precessionBreath-holdNavigator gatingElectrocardiographic (ECG) gatingMagnetic resonanceDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	T1 relaxation-enhanced steady-state Unbalanced 3D steady-state free precession Breath-hold Navigator gating Electrocardiographic (ECG) gating Magnetic resonance Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	T1 relaxation-enhanced steady-state Unbalanced 3D steady-state free precession Breath-hold Navigator gating Electrocardiographic (ECG) gating Magnetic resonance Diseases of the circulatory (Cardiovascular) system RC666-701 Robert R. Edelman Nondas Leloudas Jianing Pang Ioannis Koktzoglou Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
description	Abstract Background Recently, we reported a novel neuroimaging technique, unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS), which uses a tailored 3D unbalanced steady-state free precession (3D uSSFP) acquisition to suppress the blood pool signal while minimizing bulk motion sensitivity. In the present work, we hypothesized that 3D uSSFP might also be useful for dark blood imaging of the chest. To test the feasibility of this approach, we performed a pilot study in healthy subjects and patients undergoing cardiovascular magnetic resonance (CMR). Main body The study was approved by the hospital institutional review board. Thirty-one adult subjects were imaged at 1.5 T, including 5 healthy adult subjects and 26 patients (44 to 86 years, 10 female) undergoing a clinically indicated CMR. Breath-holding was used in 29 subjects and navigator gating in 2 subjects. For breath-hold acquisitions, the 3D uSSFP pulse sequence used a high sampling bandwidth, asymmetric readout, and single-shot along the phase-encoding direction, while 3 shots were acquired for navigator-gated scans. To minimize signal dephasing from bulk motion, electrocardiographic (ECG) gating was used to synchronize the data acquisition to the diastolic phase of the cardiac cycle. To further reduce motion sensitivity, the moment of the dephasing gradient was set to one-fifth of the moment of the readout gradient. Image quality using 3D uSSFP was good-to-excellent in all subjects. The blood pool signal in the thoracic aorta was uniformly suppressed with sharp delineation of the aortic wall including two cases of ascending aortic aneurysm and two cases of aortic dissection. Compared with variable flip angle 3D turbo spin-echo, 3D uSSFP showed improved aortic wall sharpness. It was also more efficient, permitting the acquisition of 24 slices in each breath-hold versus 16 slices with 3D turbo spin-echo and a single slice with dual inversion 2D turbo spin-echo. In addition, lung and mediastinal lesions appeared highly conspicuous compared with the low blood pool signals within the heart and blood vessels. In two subjects, navigator-gated 3D uSSFP provided excellent delineation of cardiac morphology in double oblique multiplanar reformations. Conclusion In this pilot study, we have demonstrated the feasibility of using ECG-gated 3D uSSFP for dark blood imaging of the heart, great vessels, and lungs. Further study will be required to fully optimize the technique and to assess clinical utility.
format	article
author	Robert R. Edelman Nondas Leloudas Jianing Pang Ioannis Koktzoglou
author_facet	Robert R. Edelman Nondas Leloudas Jianing Pang Ioannis Koktzoglou
author_sort	Robert R. Edelman
title	Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
title_short	Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
title_full	Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
title_fullStr	Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
title_full_unstemmed	Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
title_sort	dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession
publisher	BMC
publishDate	2021
url	https://doaj.org/article/16c6438fa25a45be85c4568853f7667e
work_keys_str_mv	AT robertredelman darkbloodcardiovascularmagneticresonanceoftheheartgreatvesselsandlungsusingelectrocardiographicgatedthreedimensionalunbalancedsteadystatefreeprecession AT nondasleloudas darkbloodcardiovascularmagneticresonanceoftheheartgreatvesselsandlungsusingelectrocardiographicgatedthreedimensionalunbalancedsteadystatefreeprecession AT jianingpang darkbloodcardiovascularmagneticresonanceoftheheartgreatvesselsandlungsusingelectrocardiographicgatedthreedimensionalunbalancedsteadystatefreeprecession AT ioanniskoktzoglou darkbloodcardiovascularmagneticresonanceoftheheartgreatvesselsandlungsusingelectrocardiographicgatedthreedimensionalunbalancedsteadystatefreeprecession
_version_	1718443471327461376

Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession

Ejemplares similares