Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes

Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes

<italic>Goal:</italic> The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. <italic>Methods:</italic> We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (T...

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Detalles Bibliográficos
Autores principales: Krishna Ramajayam, A. Wolfe, Anjan Motamarry, Georges Nahhas, John Yost, Michael Yost, Dieter Haemmerich
Formato: article
Lenguaje:EN
Publicado: IEEE 2021
Materias:
Computer models
drug delivery
hyperthermia (HT)
<italic xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">in vivo</italic>
thermosensitive liposomes
Computer applications to medicine. Medical informatics
R858-859.7
Medical technology
R855-855.5
Acceso en línea:https://doaj.org/article/16c794f038424a39be8bb48bf8db18c1
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Sumario:<italic>Goal:</italic> The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. <italic>Methods:</italic> We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (TSL-DOX) delivery in mouse tumors with three HT methods (thermistor probe (T), laser (L) and water bath (WB), at 15 min and 60 min HT duration), with corroborating <italic>in vivo</italic> studies. <italic>Results:</italic> Average computer model-predicted tumor drug concentrations (&#x03BC;g/g) were 8.8(T, 15 min), 21.0(T, 60 min), 14.1(L, 15 min), 25.2(L, 60 min), 9.4(WB, 15 min), and 8.7(WB, 60 min). Tumor fluorescence was increased by 2.6 &#x00D7; (T) and 1.6 &#x00D7; (L) when HT duration was extended from 15 to 60 min (p &lt; 0.05), with no increase for WB HT. Pharmacokinetic analysis confirmed that water bath HT causes rapid depletion of encapsulated TSL-DOX in systemic circulation due to the large heated tissue volume. <italic>Conclusions:</italic> Untargeted large volume HT causes poor tumor drug uptake from TSL.

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