Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes

<italic>Goal:</italic> The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. <italic>Methods:</italic> We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (T...

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Autores principales:	Krishna Ramajayam, A. Wolfe, Anjan Motamarry, Georges Nahhas, John Yost, Michael Yost, Dieter Haemmerich
Formato:	article
Lenguaje:	EN
Publicado:	IEEE 2021
Materias:	Computer models drug delivery hyperthermia (HT) <italic xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">in vivo</italic> thermosensitive liposomes Computer applications to medicine. Medical informatics R858-859.7 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/16c794f038424a39be8bb48bf8db18c1
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spelling	oai:doaj.org-article:16c794f038424a39be8bb48bf8db18c12021-11-25T00:01:12ZUntargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes2644-127610.1109/OJEMB.2021.3078843https://doaj.org/article/16c794f038424a39be8bb48bf8db18c12021-01-01T00:00:00Zhttps://ieeexplore.ieee.org/document/9428538/https://doaj.org/toc/2644-1276<italic>Goal:</italic> The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. <italic>Methods:</italic> We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (TSL-DOX) delivery in mouse tumors with three HT methods (thermistor probe (T), laser (L) and water bath (WB), at 15 min and 60 min HT duration), with corroborating <italic>in vivo</italic> studies. <italic>Results:</italic> Average computer model-predicted tumor drug concentrations (μg/g) were 8.8(T, 15 min), 21.0(T, 60 min), 14.1(L, 15 min), 25.2(L, 60 min), 9.4(WB, 15 min), and 8.7(WB, 60 min). Tumor fluorescence was increased by 2.6 × (T) and 1.6 × (L) when HT duration was extended from 15 to 60 min (p < 0.05), with no increase for WB HT. Pharmacokinetic analysis confirmed that water bath HT causes rapid depletion of encapsulated TSL-DOX in systemic circulation due to the large heated tissue volume. <italic>Conclusions:</italic> Untargeted large volume HT causes poor tumor drug uptake from TSL.Krishna RamajayamA. WolfeAnjan MotamarryGeorges NahhasJohn YostMichael YostDieter HaemmerichIEEEarticleComputer modelsdrug deliveryhyperthermia (HT)<italic xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">in vivo</italic>thermosensitive liposomesComputer applications to medicine. Medical informaticsR858-859.7Medical technologyR855-855.5ENIEEE Open Journal of Engineering in Medicine and Biology, Vol 2, Pp 187-197 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer models drug delivery hyperthermia (HT) <italic xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">in vivo</italic> thermosensitive liposomes Computer applications to medicine. Medical informatics R858-859.7 Medical technology R855-855.5
spellingShingle	Computer models drug delivery hyperthermia (HT) <italic xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">in vivo</italic> thermosensitive liposomes Computer applications to medicine. Medical informatics R858-859.7 Medical technology R855-855.5 Krishna Ramajayam A. Wolfe Anjan Motamarry Georges Nahhas John Yost Michael Yost Dieter Haemmerich Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
description	<italic>Goal:</italic> The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. <italic>Methods:</italic> We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (TSL-DOX) delivery in mouse tumors with three HT methods (thermistor probe (T), laser (L) and water bath (WB), at 15 min and 60 min HT duration), with corroborating <italic>in vivo</italic> studies. <italic>Results:</italic> Average computer model-predicted tumor drug concentrations (μg/g) were 8.8(T, 15 min), 21.0(T, 60 min), 14.1(L, 15 min), 25.2(L, 60 min), 9.4(WB, 15 min), and 8.7(WB, 60 min). Tumor fluorescence was increased by 2.6 × (T) and 1.6 × (L) when HT duration was extended from 15 to 60 min (p < 0.05), with no increase for WB HT. Pharmacokinetic analysis confirmed that water bath HT causes rapid depletion of encapsulated TSL-DOX in systemic circulation due to the large heated tissue volume. <italic>Conclusions:</italic> Untargeted large volume HT causes poor tumor drug uptake from TSL.
format	article
author	Krishna Ramajayam A. Wolfe Anjan Motamarry Georges Nahhas John Yost Michael Yost Dieter Haemmerich
author_facet	Krishna Ramajayam A. Wolfe Anjan Motamarry Georges Nahhas John Yost Michael Yost Dieter Haemmerich
author_sort	Krishna Ramajayam
title	Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
title_short	Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
title_full	Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
title_fullStr	Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
title_full_unstemmed	Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
title_sort	untargeted large volume hyperthermia reduces tumor drug uptake from thermosensitive liposomes
publisher	IEEE
publishDate	2021
url	https://doaj.org/article/16c794f038424a39be8bb48bf8db18c1
work_keys_str_mv	AT krishnaramajayam untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes AT awolfe untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes AT anjanmotamarry untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes AT georgesnahhas untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes AT johnyost untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes AT michaelyost untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes AT dieterhaemmerich untargetedlargevolumehyperthermiareducestumordruguptakefromthermosensitiveliposomes
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Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes

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