The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation

Abstract Background: Colorectal cancer causes many deaths worldwide and rectal cancer includes one-third of them. Surgical mesorectal excision along with preoperative neoadjuvant chemoradiotherapy is known as the standard treatment for rectal cancer. However, inaccurate preoperative staging is a mai...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ahmad Izadpanah, Seyed Vahid Hosseini, Maytham Al-Qanbar, Mozhdeh Zamani, Behnam Kadkhodaei
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2019
Materias:	rectal cancer adjuvant chemoradiation overall survival disease free survival Medicine R
Acceso en línea:	https://doaj.org/article/16c9b98e942148fabb7f273492d970bf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16c9b98e942148fabb7f273492d970bf
record_format	dspace
spelling	oai:doaj.org-article:16c9b98e942148fabb7f273492d970bf2021-11-14T08:42:28ZThe Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation2783-243010.30476/acrr.2019.45941https://doaj.org/article/16c9b98e942148fabb7f273492d970bf2019-12-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45941_ad7343d77b24d1ba12da5d91140720b3.pdfhttps://doaj.org/toc/2783-2430Abstract Background: Colorectal cancer causes many deaths worldwide and rectal cancer includes one-third of them. Surgical mesorectal excision along with preoperative neoadjuvant chemoradiotherapy is known as the standard treatment for rectal cancer. However, inaccurate preoperative staging is a main concern which leads to large number of patients not being treated with neoadjuvant therapy. Selection of the best treatment approach for these patients is controversial. Although significant better survival was observed is patients who received postoperative adjuvant chemoradiation compared with patients who treated with surgery alone, other studies did not find such results. Due to these contradictory results, this study was designed to further evaluate the survival outcomes in rectal cancer patients who received adjuvant chemoradiotherapy without neoadjuvant therapy. Methods: Totally 197 rectal cancer patients who received adjuvant chemoradiation were included in this study. The demographic and clinico-pathological characteristics of the patients were evaluated by statistical analysis. Results: Based on the univariate cox regression, poor disease free survival (DFS) was significantly associated with male sex and T3 stage. Poor overall survival (OS) was also associated with stage II/III, T3/T4, NI/NII, grade II/III, positive node number (> 3), perineural invasion, lymphovascular invasion, and margin involvement. According to the multivariate cox regression, independent predictive factors for DFS were T3 andT4 stage, and for OS were also T3/ T4 stage, grade II/ III and lymphovascular invasion. Conclusions: Taken together, obtained results indicated that combined adjuvant chemoradiation contributes to improve survival outcomes in the rectal cancer patients who did not received neoadjuvant therapy.Ahmad IzadpanahSeyed Vahid HosseiniMaytham Al-QanbarMozhdeh ZamaniBehnam KadkhodaeiShiraz University of Medical Sciencesarticlerectal canceradjuvant chemoradiationoverall survivaldisease free survivalMedicineRENIranian Journal of Colorectal Research, Vol 7, Iss 4, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	rectal cancer adjuvant chemoradiation overall survival disease free survival Medicine R
spellingShingle	rectal cancer adjuvant chemoradiation overall survival disease free survival Medicine R Ahmad Izadpanah Seyed Vahid Hosseini Maytham Al-Qanbar Mozhdeh Zamani Behnam Kadkhodaei The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation
description	Abstract Background: Colorectal cancer causes many deaths worldwide and rectal cancer includes one-third of them. Surgical mesorectal excision along with preoperative neoadjuvant chemoradiotherapy is known as the standard treatment for rectal cancer. However, inaccurate preoperative staging is a main concern which leads to large number of patients not being treated with neoadjuvant therapy. Selection of the best treatment approach for these patients is controversial. Although significant better survival was observed is patients who received postoperative adjuvant chemoradiation compared with patients who treated with surgery alone, other studies did not find such results. Due to these contradictory results, this study was designed to further evaluate the survival outcomes in rectal cancer patients who received adjuvant chemoradiotherapy without neoadjuvant therapy. Methods: Totally 197 rectal cancer patients who received adjuvant chemoradiation were included in this study. The demographic and clinico-pathological characteristics of the patients were evaluated by statistical analysis. Results: Based on the univariate cox regression, poor disease free survival (DFS) was significantly associated with male sex and T3 stage. Poor overall survival (OS) was also associated with stage II/III, T3/T4, NI/NII, grade II/III, positive node number (> 3), perineural invasion, lymphovascular invasion, and margin involvement. According to the multivariate cox regression, independent predictive factors for DFS were T3 andT4 stage, and for OS were also T3/ T4 stage, grade II/ III and lymphovascular invasion. Conclusions: Taken together, obtained results indicated that combined adjuvant chemoradiation contributes to improve survival outcomes in the rectal cancer patients who did not received neoadjuvant therapy.
format	article
author	Ahmad Izadpanah Seyed Vahid Hosseini Maytham Al-Qanbar Mozhdeh Zamani Behnam Kadkhodaei
author_facet	Ahmad Izadpanah Seyed Vahid Hosseini Maytham Al-Qanbar Mozhdeh Zamani Behnam Kadkhodaei
author_sort	Ahmad Izadpanah
title	The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation
title_short	The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation
title_full	The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation
title_fullStr	The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation
title_full_unstemmed	The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation
title_sort	results and outcomes of rectal cancer treatment in the era of adjuvant chemoradiation
publisher	Shiraz University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/16c9b98e942148fabb7f273492d970bf
work_keys_str_mv	AT ahmadizadpanah theresultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT seyedvahidhosseini theresultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT maythamalqanbar theresultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT mozhdehzamani theresultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT behnamkadkhodaei theresultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT ahmadizadpanah resultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT seyedvahidhosseini resultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT maythamalqanbar resultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT mozhdehzamani resultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation AT behnamkadkhodaei resultsandoutcomesofrectalcancertreatmentintheeraofadjuvantchemoradiation
_version_	1718429761422753792

The Results and Outcomes of Rectal Cancer Treatment in the Era of Adjuvant Chemoradiation

Ejemplares similares