Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.

<h4>Purpose</h4>To assess the efficacy of pregabalin by showing differences in the neuronal activities of fibromyalgia (FM) patients before and after longitudinal treatment using functional magnetic resonance imaging (fMRI).<h4>Materials and methods</h4>In total, 21 female pa...

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Autores principales:	Seong-Ho Kim, Youngho Lee, Sunggun Lee, Chi-Woong Mun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16cc053797a54af5bb2c06aeb96655ff
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spelling	oai:doaj.org-article:16cc053797a54af5bb2c06aeb96655ff2021-11-18T08:56:28ZEvaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.1932-620310.1371/journal.pone.0074099https://doaj.org/article/16cc053797a54af5bb2c06aeb96655ff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040178/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To assess the efficacy of pregabalin by showing differences in the neuronal activities of fibromyalgia (FM) patients before and after longitudinal treatment using functional magnetic resonance imaging (fMRI).<h4>Materials and methods</h4>In total, 21 female patients with FM and 11 age- and gender-matched healthy controls participated. FM patients underwent fMRI at baseline and following pharmacological therapy with pregabalin to diminish their pain. Pressure-pain stimuli were delivered on the subject's thumbnail bed during fMRI scans. Brain activation regions in fMRI were evaluated for longitudinal changes using a paired t-test. Changes in clinical features were also assessed with the Fibromyalgia Impact Questionnaire (FIQ), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), Widespread Pain Index (WPI), Symptom Severity Scale Score (SSS), and State-Trait Anxiety Inventory (STAI).<h4>Results</h4>Clinical scores were reduced significantly following therapy with five of the six clinical tests (FIQ, BFI, BDI, WPI, SSS; p < 0.05). Brain activation post-treatment was significantly lower than that pre-treatment in 13 regions of the brain (p < 0.001).<h4>Conclusions</h4>Our findings confirm that pregabalin influences aspects of the whole pain matrix, using fMRI, inducing longitudinal changes in neuronal activity during the pain state, and that it reduces pain and other core symptoms of FM. This method could be applied to other longitudinal clinical trials of pharmacological treatments for FM.Seong-Ho KimYoungho LeeSunggun LeeChi-Woong MunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74099 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seong-Ho Kim Youngho Lee Sunggun Lee Chi-Woong Mun Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
description	<h4>Purpose</h4>To assess the efficacy of pregabalin by showing differences in the neuronal activities of fibromyalgia (FM) patients before and after longitudinal treatment using functional magnetic resonance imaging (fMRI).<h4>Materials and methods</h4>In total, 21 female patients with FM and 11 age- and gender-matched healthy controls participated. FM patients underwent fMRI at baseline and following pharmacological therapy with pregabalin to diminish their pain. Pressure-pain stimuli were delivered on the subject's thumbnail bed during fMRI scans. Brain activation regions in fMRI were evaluated for longitudinal changes using a paired t-test. Changes in clinical features were also assessed with the Fibromyalgia Impact Questionnaire (FIQ), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), Widespread Pain Index (WPI), Symptom Severity Scale Score (SSS), and State-Trait Anxiety Inventory (STAI).<h4>Results</h4>Clinical scores were reduced significantly following therapy with five of the six clinical tests (FIQ, BFI, BDI, WPI, SSS; p < 0.05). Brain activation post-treatment was significantly lower than that pre-treatment in 13 regions of the brain (p < 0.001).<h4>Conclusions</h4>Our findings confirm that pregabalin influences aspects of the whole pain matrix, using fMRI, inducing longitudinal changes in neuronal activity during the pain state, and that it reduces pain and other core symptoms of FM. This method could be applied to other longitudinal clinical trials of pharmacological treatments for FM.
format	article
author	Seong-Ho Kim Youngho Lee Sunggun Lee Chi-Woong Mun
author_facet	Seong-Ho Kim Youngho Lee Sunggun Lee Chi-Woong Mun
author_sort	Seong-Ho Kim
title	Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
title_short	Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
title_full	Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
title_fullStr	Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
title_full_unstemmed	Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
title_sort	evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/16cc053797a54af5bb2c06aeb96655ff
work_keys_str_mv	AT seonghokim evaluationoftheeffectivenessofpregabalininalleviatingpainassociatedwithfibromyalgiausingfunctionalmagneticresonanceimagingstudy AT youngholee evaluationoftheeffectivenessofpregabalininalleviatingpainassociatedwithfibromyalgiausingfunctionalmagneticresonanceimagingstudy AT sunggunlee evaluationoftheeffectivenessofpregabalininalleviatingpainassociatedwithfibromyalgiausingfunctionalmagneticresonanceimagingstudy AT chiwoongmun evaluationoftheeffectivenessofpregabalininalleviatingpainassociatedwithfibromyalgiausingfunctionalmagneticresonanceimagingstudy
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Evaluation of the effectiveness of pregabalin in alleviating pain associated with fibromyalgia: using functional magnetic resonance imaging study.

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