Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons

Abstract Influenza immunization protects seniors against influenza and its potentially serious complications. It is uncertain whether standard-dose (SD) quadrivalent vaccine offers better protection over other formulations in the elderly. In this study, we compared the effectiveness of SD-trivalent,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marina Amaral de Avila Machado, Cristiano S. Moura, Michal Abrahamowicz, Brian J. Ward, Louise Pilote, Sasha Bernatsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/16d34eec619e49e28a213b93a7fd6f96
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16d34eec619e49e28a213b93a7fd6f96
record_format	dspace
spelling	oai:doaj.org-article:16d34eec619e49e28a213b93a7fd6f962021-12-02T16:34:57ZRelative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons10.1038/s41541-021-00373-w2059-0105https://doaj.org/article/16d34eec619e49e28a213b93a7fd6f962021-08-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00373-whttps://doaj.org/toc/2059-0105Abstract Influenza immunization protects seniors against influenza and its potentially serious complications. It is uncertain whether standard-dose (SD) quadrivalent vaccine offers better protection over other formulations in the elderly. In this study, we compared the effectiveness of SD-trivalent, high-dose (HD) trivalent, SD-quadrivalent, and adjuvanted trivalent vaccines in seniors (≥65 years) in a real-world setting. We selected over 200,000 individuals in each of 6 influenza seasons from 2012 to 2018 using MarketScan® databases. The two outcomes were hospitalization or emergency room (ER) visit due to (1) influenza or (2) pneumonia. Here, SD-quadrivalent was associated with higher risk of influenza-related hospitalization/ER visit (adjusted hazard ratio (aHR) 1.14 and 95% confidence interval (95% CI) 1.05–1.24) and of pneumonia-related hospitalization/ER visit (aHR 1.04 and 95% CI 1.01–1.07) vs. HD-trivalent. SD-trivalent followed similar trends compared to HD-trivalent (aHR 1.16 and 95% CI 1.06–1.27 for hospitalized/ER visit influenza; aHR 1.07 and 95% CI 1.05–1.10 for hospitalized/ER visit pneumonia). We could not demonstrate risk differences between SD vaccine formulations and between adjuvanted trivalent and one of the other three vaccines. Risk estimates slightly varied across seasons. These findings suggest that SD vaccine formulations vs. HD-trivalent were associated with higher risk of hospitalization/ER visit for influenza and pneumonia in seniors.Marina Amaral de Avila MachadoCristiano S. MouraMichal AbrahamowiczBrian J. WardLouise PiloteSasha BernatskyNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marina Amaral de Avila Machado Cristiano S. Moura Michal Abrahamowicz Brian J. Ward Louise Pilote Sasha Bernatsky Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons
description	Abstract Influenza immunization protects seniors against influenza and its potentially serious complications. It is uncertain whether standard-dose (SD) quadrivalent vaccine offers better protection over other formulations in the elderly. In this study, we compared the effectiveness of SD-trivalent, high-dose (HD) trivalent, SD-quadrivalent, and adjuvanted trivalent vaccines in seniors (≥65 years) in a real-world setting. We selected over 200,000 individuals in each of 6 influenza seasons from 2012 to 2018 using MarketScan® databases. The two outcomes were hospitalization or emergency room (ER) visit due to (1) influenza or (2) pneumonia. Here, SD-quadrivalent was associated with higher risk of influenza-related hospitalization/ER visit (adjusted hazard ratio (aHR) 1.14 and 95% confidence interval (95% CI) 1.05–1.24) and of pneumonia-related hospitalization/ER visit (aHR 1.04 and 95% CI 1.01–1.07) vs. HD-trivalent. SD-trivalent followed similar trends compared to HD-trivalent (aHR 1.16 and 95% CI 1.06–1.27 for hospitalized/ER visit influenza; aHR 1.07 and 95% CI 1.05–1.10 for hospitalized/ER visit pneumonia). We could not demonstrate risk differences between SD vaccine formulations and between adjuvanted trivalent and one of the other three vaccines. Risk estimates slightly varied across seasons. These findings suggest that SD vaccine formulations vs. HD-trivalent were associated with higher risk of hospitalization/ER visit for influenza and pneumonia in seniors.
format	article
author	Marina Amaral de Avila Machado Cristiano S. Moura Michal Abrahamowicz Brian J. Ward Louise Pilote Sasha Bernatsky
author_facet	Marina Amaral de Avila Machado Cristiano S. Moura Michal Abrahamowicz Brian J. Ward Louise Pilote Sasha Bernatsky
author_sort	Marina Amaral de Avila Machado
title	Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons
title_short	Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons
title_full	Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons
title_fullStr	Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons
title_full_unstemmed	Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons
title_sort	relative effectiveness of influenza vaccines in elderly persons in the united states, 2012/2013-2017/2018 seasons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16d34eec619e49e28a213b93a7fd6f96
work_keys_str_mv	AT marinaamaraldeavilamachado relativeeffectivenessofinfluenzavaccinesinelderlypersonsintheunitedstates2012201320172018seasons AT cristianosmoura relativeeffectivenessofinfluenzavaccinesinelderlypersonsintheunitedstates2012201320172018seasons AT michalabrahamowicz relativeeffectivenessofinfluenzavaccinesinelderlypersonsintheunitedstates2012201320172018seasons AT brianjward relativeeffectivenessofinfluenzavaccinesinelderlypersonsintheunitedstates2012201320172018seasons AT louisepilote relativeeffectivenessofinfluenzavaccinesinelderlypersonsintheunitedstates2012201320172018seasons AT sashabernatsky relativeeffectivenessofinfluenzavaccinesinelderlypersonsintheunitedstates2012201320172018seasons
_version_	1718383737034506240

Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons

Ejemplares similares