Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons that are dynamically regulated by CB1 agonists.

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Detalles Bibliográficos
Autores principales: Hui Li, Jie Yang, Cuiping Tian, Min Diao, Quan Wang, Simeng Zhao, Shanshan Li, Fangzhi Tan, Tian Hua, Ya Qin, Chao-Po Lin, Dylan Deska-Gauthier, Garth J. Thompson, Ying Zhang, Wenqing Shui, Zhi-Jie Liu, Tong Wang, Guisheng Zhong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
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Acceso en línea:https://doaj.org/article/16d642a130464ca1a75800a5fd41828b
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Descripción
Sumario:Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons that are dynamically regulated by CB1 agonists.

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