Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds

Articular cartilage, which is a white transparent tissue with 1–2 mm thickness, is located in the interface between the two hard bones. The main functions of articular cartilage are stress transmission, absorption, and friction reduction. The cartilage cannot be repaired and regenerated once it has...

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Autores principales:	Yi-Wen Chen, Ming-You Shie, Wen-Ching Chang, Yu-Fang Shen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cartilage scaffold light curing waterborne polyurethane digital light processing design of experiments Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/16d71e927e7046df8eee231ec9a3495e
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spelling	oai:doaj.org-article:16d71e927e7046df8eee231ec9a3495e2021-11-25T18:13:41ZApproximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds10.3390/ma142268041996-1944https://doaj.org/article/16d71e927e7046df8eee231ec9a3495e2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6804https://doaj.org/toc/1996-1944Articular cartilage, which is a white transparent tissue with 1–2 mm thickness, is located in the interface between the two hard bones. The main functions of articular cartilage are stress transmission, absorption, and friction reduction. The cartilage cannot be repaired and regenerated once it has been damaged, and it needs to be replaced by artificial joints. Many approaches, such as artificial joint replacement, hyaluronic acid injection, microfracture surgery and cartilage tissue engineering have been applied in clinical treatment. Basically, some of these approaches are foreign material implantation for joint replacement to reach the goal of pain reduction and mechanism support. This study demonstrated another frontier in the research of cartilage reconstruction by applying regeneration medicine additive manufacturing (3D Printing) and stem cell technology. Light curing materials have been modified and tested to be printable and cytocompatible for stem cells in this research. Design of experiments (DOE) is adapted in this investigation to search for the optimal manufacturing parameter for biocompatible scaffold fabrication and stem cell attachment and growth. Based on the results, an optimal working process of biocompatible and printable scaffolds for cartilage regeneration is reported. We expect this study will facilitate the development of cartilage tissue engineering.Yi-Wen ChenMing-You ShieWen-Ching ChangYu-Fang ShenMDPI AGarticlecartilage scaffoldlight curing waterborne polyurethanedigital light processingdesign of experimentsTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6804, p 6804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cartilage scaffold light curing waterborne polyurethane digital light processing design of experiments Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	cartilage scaffold light curing waterborne polyurethane digital light processing design of experiments Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Yi-Wen Chen Ming-You Shie Wen-Ching Chang Yu-Fang Shen Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds
description	Articular cartilage, which is a white transparent tissue with 1–2 mm thickness, is located in the interface between the two hard bones. The main functions of articular cartilage are stress transmission, absorption, and friction reduction. The cartilage cannot be repaired and regenerated once it has been damaged, and it needs to be replaced by artificial joints. Many approaches, such as artificial joint replacement, hyaluronic acid injection, microfracture surgery and cartilage tissue engineering have been applied in clinical treatment. Basically, some of these approaches are foreign material implantation for joint replacement to reach the goal of pain reduction and mechanism support. This study demonstrated another frontier in the research of cartilage reconstruction by applying regeneration medicine additive manufacturing (3D Printing) and stem cell technology. Light curing materials have been modified and tested to be printable and cytocompatible for stem cells in this research. Design of experiments (DOE) is adapted in this investigation to search for the optimal manufacturing parameter for biocompatible scaffold fabrication and stem cell attachment and growth. Based on the results, an optimal working process of biocompatible and printable scaffolds for cartilage regeneration is reported. We expect this study will facilitate the development of cartilage tissue engineering.
format	article
author	Yi-Wen Chen Ming-You Shie Wen-Ching Chang Yu-Fang Shen
author_facet	Yi-Wen Chen Ming-You Shie Wen-Ching Chang Yu-Fang Shen
author_sort	Yi-Wen Chen
title	Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds
title_short	Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds
title_full	Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds
title_fullStr	Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds
title_full_unstemmed	Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds
title_sort	approximate optimization study of light curing waterborne polyurethane materials for the construction of 3d printed cytocompatible cartilage scaffolds
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/16d71e927e7046df8eee231ec9a3495e
work_keys_str_mv	AT yiwenchen approximateoptimizationstudyoflightcuringwaterbornepolyurethanematerialsfortheconstructionof3dprintedcytocompatiblecartilagescaffolds AT mingyoushie approximateoptimizationstudyoflightcuringwaterbornepolyurethanematerialsfortheconstructionof3dprintedcytocompatiblecartilagescaffolds AT wenchingchang approximateoptimizationstudyoflightcuringwaterbornepolyurethanematerialsfortheconstructionof3dprintedcytocompatiblecartilagescaffolds AT yufangshen approximateoptimizationstudyoflightcuringwaterbornepolyurethanematerialsfortheconstructionof3dprintedcytocompatiblecartilagescaffolds
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Approximate Optimization Study of Light Curing Waterborne Polyurethane Materials for the Construction of 3D Printed Cytocompatible Cartilage Scaffolds

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