Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer

Xiaolin Li,1,* Hua&rsquo;e Xu,2,* Xinzheng Dai,3,4,* Zhenshu Zhu,5 Baorui Liu,6 Xiaowei Lu11Department of Geriatrics, 2Department of Pharmacy, the First Affiliated Hospital to Nanjing Medical University, Nanjing; 3Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Healt...

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Autores principales:	Li X, Xu H, Dai X, Zhu Z, Liu B, Lu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/16d9269c0cd44bc8bea396dfcb9d7442
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spelling	oai:doaj.org-article:16d9269c0cd44bc8bea396dfcb9d74422021-12-02T05:24:33ZEnhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer1176-91141178-2013https://doaj.org/article/16d9269c0cd44bc8bea396dfcb9d74422012-10-01T00:00:00Zhttp://www.dovepress.com/enhanced-in-vitro-and-in-vivo-therapeutic-efficacy-of-codrug-loaded-na-a11166https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xiaolin Li,1,* Hua&rsquo;e Xu,2,* Xinzheng Dai,3,4,* Zhenshu Zhu,5 Baorui Liu,6 Xiaowei Lu11Department of Geriatrics, 2Department of Pharmacy, the First Affiliated Hospital to Nanjing Medical University, Nanjing; 3Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health, 4Liver Transplantation Center, the First Affiliated Hospital to Nanjing Medical University, Nanjing; 5Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing; 6The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China*These authors contributed equally to this workAbstract: Paclitaxel (Ptx), one of the most widely used anticancer agents, has demonstrated extraordinary activities against a variety of solid tumors. However, the therapeutic response of Ptx is often associated with severe side effects caused by its nonspecific cytotoxic effects and special solvents (Cremophor EL&reg;). The current study reports the stable controlled release of Ptx/tetrandrine (Tet)-coloaded nanoparticles by amphilic methoxy poly(ethylene glycol)&ndash;poly(caprolactone) block copolymers. There were three significant findings. Firstly, Tet could effectively stabilize Ptx-loaded nanoparticles with the coencapsulation of Tet and Ptx. The influence of different Ptx/Tet feeding ratios on the size and loading efficiency of the nanoparticles was also explored. Secondly, the encapsulation of Tet and Ptx into nanoparticles retains the synergistic anticancer efficiency of Tet and Ptx against mice hepatoma H22 cells. Thirdly, in the in vivo evaluation, intratumoral administration was adopted to increase the site-specific delivery. Ptx/Tet nanoparticles, when delivered intratumorally, exhibited significantly improved antitumor efficacy; moreover, they substantially increased the overall survival in an established H22-transplanted mice model. Further investigation into the anticancer mechanisms of this nanodelivery system is under active consideration as a part of this ongoing research. The results suggest that Ptx/Tet-coloaded nanoparticles could be a potential useful chemotherapeutic formulation for liver cancer therapy.Keywords: tetrandrine, paclitaxel, nanoparticle, liver cancerLi XXu HDai XZhu ZLiu BLu XDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5183-5190 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li X Xu H Dai X Zhu Z Liu B Lu X Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
description	Xiaolin Li,1,* Hua&rsquo;e Xu,2,* Xinzheng Dai,3,4,* Zhenshu Zhu,5 Baorui Liu,6 Xiaowei Lu11Department of Geriatrics, 2Department of Pharmacy, the First Affiliated Hospital to Nanjing Medical University, Nanjing; 3Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health, 4Liver Transplantation Center, the First Affiliated Hospital to Nanjing Medical University, Nanjing; 5Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing; 6The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China*These authors contributed equally to this workAbstract: Paclitaxel (Ptx), one of the most widely used anticancer agents, has demonstrated extraordinary activities against a variety of solid tumors. However, the therapeutic response of Ptx is often associated with severe side effects caused by its nonspecific cytotoxic effects and special solvents (Cremophor EL&reg;). The current study reports the stable controlled release of Ptx/tetrandrine (Tet)-coloaded nanoparticles by amphilic methoxy poly(ethylene glycol)&ndash;poly(caprolactone) block copolymers. There were three significant findings. Firstly, Tet could effectively stabilize Ptx-loaded nanoparticles with the coencapsulation of Tet and Ptx. The influence of different Ptx/Tet feeding ratios on the size and loading efficiency of the nanoparticles was also explored. Secondly, the encapsulation of Tet and Ptx into nanoparticles retains the synergistic anticancer efficiency of Tet and Ptx against mice hepatoma H22 cells. Thirdly, in the in vivo evaluation, intratumoral administration was adopted to increase the site-specific delivery. Ptx/Tet nanoparticles, when delivered intratumorally, exhibited significantly improved antitumor efficacy; moreover, they substantially increased the overall survival in an established H22-transplanted mice model. Further investigation into the anticancer mechanisms of this nanodelivery system is under active consideration as a part of this ongoing research. The results suggest that Ptx/Tet-coloaded nanoparticles could be a potential useful chemotherapeutic formulation for liver cancer therapy.Keywords: tetrandrine, paclitaxel, nanoparticle, liver cancer
format	article
author	Li X Xu H Dai X Zhu Z Liu B Lu X
author_facet	Li X Xu H Dai X Zhu Z Liu B Lu X
author_sort	Li X
title	Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
title_short	Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
title_full	Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
title_fullStr	Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
title_full_unstemmed	Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
title_sort	enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/16d9269c0cd44bc8bea396dfcb9d7442
work_keys_str_mv	AT lix enhancedinvitroandinvivotherapeuticefficacyofcodrugloadednanoparticlesagainstlivercancer AT xuh enhancedinvitroandinvivotherapeuticefficacyofcodrugloadednanoparticlesagainstlivercancer AT daix enhancedinvitroandinvivotherapeuticefficacyofcodrugloadednanoparticlesagainstlivercancer AT zhuz enhancedinvitroandinvivotherapeuticefficacyofcodrugloadednanoparticlesagainstlivercancer AT liub enhancedinvitroandinvivotherapeuticefficacyofcodrugloadednanoparticlesagainstlivercancer AT lux enhancedinvitroandinvivotherapeuticefficacyofcodrugloadednanoparticlesagainstlivercancer
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Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer

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