Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.

Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure....

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Autores principales:	Bernhard Sehm, Stefan Frisch, Angelika Thöne-Otto, Annette Horstmann, Arno Villringer, Hellmuth Obrig
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16dd4952cac54ba5b8be02b12238b205
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spelling	oai:doaj.org-article:16dd4952cac54ba5b8be02b12238b2052021-11-18T07:36:14ZFocal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.1932-620310.1371/journal.pone.0026538https://doaj.org/article/16dd4952cac54ba5b8be02b12238b2052011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22028902/?tool=EBIhttps://doaj.org/toc/1932-6203Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n = 20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not show abnormalities in clinical radiological assessment, but show distinct neuropsychological deficits.Bernhard SehmStefan FrischAngelika Thöne-OttoAnnette HorstmannArno VillringerHellmuth ObrigPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26538 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernhard Sehm Stefan Frisch Angelika Thöne-Otto Annette Horstmann Arno Villringer Hellmuth Obrig Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.
description	Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n = 20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was paralleled by grey matter differences in central nodes of the retrograde memory network. We therefore suggest that these subtle alterations represent structural correlates of the focal retrograde amnesia in our patient. Beyond the implications for the diagnosis and etiology of FRA, our results advocate the use of VBM in conditions that do not show abnormalities in clinical radiological assessment, but show distinct neuropsychological deficits.
format	article
author	Bernhard Sehm Stefan Frisch Angelika Thöne-Otto Annette Horstmann Arno Villringer Hellmuth Obrig
author_facet	Bernhard Sehm Stefan Frisch Angelika Thöne-Otto Annette Horstmann Arno Villringer Hellmuth Obrig
author_sort	Bernhard Sehm
title	Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.
title_short	Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.
title_full	Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.
title_fullStr	Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.
title_full_unstemmed	Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.
title_sort	focal retrograde amnesia: voxel-based morphometry findings in a case without mri lesions.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/16dd4952cac54ba5b8be02b12238b205
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Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions.

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