Lower synaptic density is associated with depression severity and network alterations

Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is lower in those with more severe symptoms of depre...

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Autores principales:	Sophie E. Holmes, Dustin Scheinost, Sjoerd J. Finnema, Mika Naganawa, Margaret T. Davis, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo A. Angarita, Robert H. Pietrzak, Ronald S. Duman, Gerard Sanacora, John H. Krystal, Richard E. Carson, Irina Esterlis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16df126356f84726bd48b72d3e90f6bf
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spelling	oai:doaj.org-article:16df126356f84726bd48b72d3e90f6bf2021-12-02T16:58:24ZLower synaptic density is associated with depression severity and network alterations10.1038/s41467-019-09562-72041-1723https://doaj.org/article/16df126356f84726bd48b72d3e90f6bf2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09562-7https://doaj.org/toc/2041-1723Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is lower in those with more severe symptoms of depression.Sophie E. HolmesDustin ScheinostSjoerd J. FinnemaMika NaganawaMargaret T. DavisNicole DellaGioiaNabeel NabulsiDavid MatuskeyGustavo A. AngaritaRobert H. PietrzakRonald S. DumanGerard SanacoraJohn H. KrystalRichard E. CarsonIrina EsterlisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sophie E. Holmes Dustin Scheinost Sjoerd J. Finnema Mika Naganawa Margaret T. Davis Nicole DellaGioia Nabeel Nabulsi David Matuskey Gustavo A. Angarita Robert H. Pietrzak Ronald S. Duman Gerard Sanacora John H. Krystal Richard E. Carson Irina Esterlis Lower synaptic density is associated with depression severity and network alterations
description	Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is lower in those with more severe symptoms of depression.
format	article
author	Sophie E. Holmes Dustin Scheinost Sjoerd J. Finnema Mika Naganawa Margaret T. Davis Nicole DellaGioia Nabeel Nabulsi David Matuskey Gustavo A. Angarita Robert H. Pietrzak Ronald S. Duman Gerard Sanacora John H. Krystal Richard E. Carson Irina Esterlis
author_facet	Sophie E. Holmes Dustin Scheinost Sjoerd J. Finnema Mika Naganawa Margaret T. Davis Nicole DellaGioia Nabeel Nabulsi David Matuskey Gustavo A. Angarita Robert H. Pietrzak Ronald S. Duman Gerard Sanacora John H. Krystal Richard E. Carson Irina Esterlis
author_sort	Sophie E. Holmes
title	Lower synaptic density is associated with depression severity and network alterations
title_short	Lower synaptic density is associated with depression severity and network alterations
title_full	Lower synaptic density is associated with depression severity and network alterations
title_fullStr	Lower synaptic density is associated with depression severity and network alterations
title_full_unstemmed	Lower synaptic density is associated with depression severity and network alterations
title_sort	lower synaptic density is associated with depression severity and network alterations
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/16df126356f84726bd48b72d3e90f6bf
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_version_	1718382312973926400

Lower synaptic density is associated with depression severity and network alterations

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