Ocular findings among patients surviving COVID-19

Abstract To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonom...

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Autores principales:	Ílen Ferreira Costa, Livia Pimenta Bonifácio, Fernando Bellissimo-Rodrigues, Eduardo Melani Rocha, Rodrigo Jorge, Valdes Roberto Bollela, Rosalia Antunes-Foschini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16e16cefa7524bd9b62cf6cbfc4a433b
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spelling	oai:doaj.org-article:16e16cefa7524bd9b62cf6cbfc4a433b2021-12-02T14:47:30ZOcular findings among patients surviving COVID-1910.1038/s41598-021-90482-22045-2322https://doaj.org/article/16e16cefa7524bd9b62cf6cbfc4a433b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90482-2https://doaj.org/toc/2045-2322Abstract To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmoscopy, color fundus picture, and retinal architecture evaluation using optical coherence tomography. Socio-demographic data and personal medical history were also collected. According to the severity of systemic manifestations, patients were classified into mild-to-moderate, severe, and critical. Sixty-four patients (128 eyes) were evaluated 82 ± 36.4 days after the onset of COVID’s symptoms. The mean ± SD duration of hospitalization was 15.0 ± 10.7 days. Seven patients (10.9%) had mild-to-moderate, 33 (51.5%) severe, and 24 (37.5%) critical disease. Median [interquartile ranges (IQR)] presenting visual acuity was 0.1 (0–0.2) and BCVA 0 (0–0.1). Anterior segment biomicroscopy was unremarkable, except for dry eye disease, verified in 10.9% of them. The mean ± SD intraocular pressure (IOP) in critical group (14.16 ± 1.88 mmHg) was significantly higher than in severe group (12.51 ± 2.40 mmHg), both in the right (p 0.02) and left eyes (p 0.038). Among all, 15.6% had diabetic retinopathy, and two patients presented with discrete white-yellowish dots in the posterior pole, leading to hyporreflective changes at retinal pigment epithelium level, outer segment, and ellipsoid layers. The present study identified higher IOP among critical cases, when compared to severe cases, and discrete outer retina changes 80 days after COVID-19 infection. No sign of uveitis was found.Ílen Ferreira CostaLivia Pimenta BonifácioFernando Bellissimo-RodriguesEduardo Melani RochaRodrigo JorgeValdes Roberto BollelaRosalia Antunes-FoschiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ílen Ferreira Costa Livia Pimenta Bonifácio Fernando Bellissimo-Rodrigues Eduardo Melani Rocha Rodrigo Jorge Valdes Roberto Bollela Rosalia Antunes-Foschini Ocular findings among patients surviving COVID-19
description	Abstract To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmoscopy, color fundus picture, and retinal architecture evaluation using optical coherence tomography. Socio-demographic data and personal medical history were also collected. According to the severity of systemic manifestations, patients were classified into mild-to-moderate, severe, and critical. Sixty-four patients (128 eyes) were evaluated 82 ± 36.4 days after the onset of COVID’s symptoms. The mean ± SD duration of hospitalization was 15.0 ± 10.7 days. Seven patients (10.9%) had mild-to-moderate, 33 (51.5%) severe, and 24 (37.5%) critical disease. Median [interquartile ranges (IQR)] presenting visual acuity was 0.1 (0–0.2) and BCVA 0 (0–0.1). Anterior segment biomicroscopy was unremarkable, except for dry eye disease, verified in 10.9% of them. The mean ± SD intraocular pressure (IOP) in critical group (14.16 ± 1.88 mmHg) was significantly higher than in severe group (12.51 ± 2.40 mmHg), both in the right (p 0.02) and left eyes (p 0.038). Among all, 15.6% had diabetic retinopathy, and two patients presented with discrete white-yellowish dots in the posterior pole, leading to hyporreflective changes at retinal pigment epithelium level, outer segment, and ellipsoid layers. The present study identified higher IOP among critical cases, when compared to severe cases, and discrete outer retina changes 80 days after COVID-19 infection. No sign of uveitis was found.
format	article
author	Ílen Ferreira Costa Livia Pimenta Bonifácio Fernando Bellissimo-Rodrigues Eduardo Melani Rocha Rodrigo Jorge Valdes Roberto Bollela Rosalia Antunes-Foschini
author_facet	Ílen Ferreira Costa Livia Pimenta Bonifácio Fernando Bellissimo-Rodrigues Eduardo Melani Rocha Rodrigo Jorge Valdes Roberto Bollela Rosalia Antunes-Foschini
author_sort	Ílen Ferreira Costa
title	Ocular findings among patients surviving COVID-19
title_short	Ocular findings among patients surviving COVID-19
title_full	Ocular findings among patients surviving COVID-19
title_fullStr	Ocular findings among patients surviving COVID-19
title_full_unstemmed	Ocular findings among patients surviving COVID-19
title_sort	ocular findings among patients surviving covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16e16cefa7524bd9b62cf6cbfc4a433b
work_keys_str_mv	AT ilenferreiracosta ocularfindingsamongpatientssurvivingcovid19 AT liviapimentabonifacio ocularfindingsamongpatientssurvivingcovid19 AT fernandobellissimorodrigues ocularfindingsamongpatientssurvivingcovid19 AT eduardomelanirocha ocularfindingsamongpatientssurvivingcovid19 AT rodrigojorge ocularfindingsamongpatientssurvivingcovid19 AT valdesrobertobollela ocularfindingsamongpatientssurvivingcovid19 AT rosaliaantunesfoschini ocularfindingsamongpatientssurvivingcovid19
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Ocular findings among patients surviving COVID-19

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