Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.

<h4>Background</h4>Lymphopenia is associated with various pathologies such as sepsis, burns, trauma, general anesthesia and major surgeries. All these pathologies are clinically expressed by the so-called Systemic Inflammatory Response Syndrome which does not include lymphopenia into def...

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Autores principales:	Juan Carlos Andreu-Ballester, Aurelio Pons-Castillo, Antonio González-Sánchez, Antonio Llombart-Cussac, María José Cano, Carmen Cuéllar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16e270d258bb4acfa3a0d27a05dd4788
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spelling	oai:doaj.org-article:16e270d258bb4acfa3a0d27a05dd47882021-12-02T20:18:08ZLymphopenia in hospitalized patients and its relationship with severity of illness and mortality.1932-620310.1371/journal.pone.0256205https://doaj.org/article/16e270d258bb4acfa3a0d27a05dd47882021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256205https://doaj.org/toc/1932-6203<h4>Background</h4>Lymphopenia is associated with various pathologies such as sepsis, burns, trauma, general anesthesia and major surgeries. All these pathologies are clinically expressed by the so-called Systemic Inflammatory Response Syndrome which does not include lymphopenia into defining criteria. The main objective of this work was to analyze the diagnosis of patients admitted to a hospital related to lymphopenia during hospital stay. In addition, we investigated the relationship of lymphopenia with the four levels of the Severity of Illness (SOI) and the Risk of Mortality (ROM).<h4>Method and findings</h4>Lymphopenia was defined as Absolute Lymphocyte Count (ALC) <1.0 x109/L. ALC were analyzed every day since admission. The four levels (minor, moderate, major and extreme risk) of both SOI and ROM were assessed. A total of 58,260 hospital admissions were analyzed. More than 41% of the patients had lymphopenia during hospital stay. The mean time to death was shorter among patients with lymphopenia on admission 65.6 days (CI95%, 57.3-73.8) vs 89.9 (CI95%, 82.4-97.4), P<0.001. Also, patients with lymphopenia during hospital stay had a shorter time to the mortality, 67.5 (CI95%, 61.1-73.9) vs 96.9 (CI95%, 92.6-101.2), P<0.001.<h4>Conclusions</h4>Lymphopenia had a high prevalence in hospitalized patients with greater relevance in infectious pathologies. Lymphopenia was related and clearly predicts SOI and ROM at the time of admission, and should be considered as clinical diagnostic criteria to define SIRS.Juan Carlos Andreu-BallesterAurelio Pons-CastilloAntonio González-SánchezAntonio Llombart-CussacMaría José CanoCarmen CuéllarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Carlos Andreu-Ballester Aurelio Pons-Castillo Antonio González-Sánchez Antonio Llombart-Cussac María José Cano Carmen Cuéllar Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
description	<h4>Background</h4>Lymphopenia is associated with various pathologies such as sepsis, burns, trauma, general anesthesia and major surgeries. All these pathologies are clinically expressed by the so-called Systemic Inflammatory Response Syndrome which does not include lymphopenia into defining criteria. The main objective of this work was to analyze the diagnosis of patients admitted to a hospital related to lymphopenia during hospital stay. In addition, we investigated the relationship of lymphopenia with the four levels of the Severity of Illness (SOI) and the Risk of Mortality (ROM).<h4>Method and findings</h4>Lymphopenia was defined as Absolute Lymphocyte Count (ALC) <1.0 x109/L. ALC were analyzed every day since admission. The four levels (minor, moderate, major and extreme risk) of both SOI and ROM were assessed. A total of 58,260 hospital admissions were analyzed. More than 41% of the patients had lymphopenia during hospital stay. The mean time to death was shorter among patients with lymphopenia on admission 65.6 days (CI95%, 57.3-73.8) vs 89.9 (CI95%, 82.4-97.4), P<0.001. Also, patients with lymphopenia during hospital stay had a shorter time to the mortality, 67.5 (CI95%, 61.1-73.9) vs 96.9 (CI95%, 92.6-101.2), P<0.001.<h4>Conclusions</h4>Lymphopenia had a high prevalence in hospitalized patients with greater relevance in infectious pathologies. Lymphopenia was related and clearly predicts SOI and ROM at the time of admission, and should be considered as clinical diagnostic criteria to define SIRS.
format	article
author	Juan Carlos Andreu-Ballester Aurelio Pons-Castillo Antonio González-Sánchez Antonio Llombart-Cussac María José Cano Carmen Cuéllar
author_facet	Juan Carlos Andreu-Ballester Aurelio Pons-Castillo Antonio González-Sánchez Antonio Llombart-Cussac María José Cano Carmen Cuéllar
author_sort	Juan Carlos Andreu-Ballester
title	Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
title_short	Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
title_full	Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
title_fullStr	Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
title_full_unstemmed	Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
title_sort	lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/16e270d258bb4acfa3a0d27a05dd4788
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Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.

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