Bacterial Ghosts-Based Vaccine and Drug Delivery Systems

Bacterial ghosts (BGs) are empty bacterial envelopes of Gram-negative bacteria produced by controlled expressions of cloned gene E, forming a lysis tunnel structure within the envelope of the living bacteria. Globally, BGs have been used as vaccine delivery systems and vaccine adjuvants. There is an...

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Autores principales:	Haojie Chen, Hao Ji, Xiangjun Kong, Pengyu Lei, Qinsi Yang, Wei Wu, Libo Jin, Da Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bacterial ghosts gene E vaccines immune delivery system Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/16e2e698795e43da90d8453292c53ea7
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id	oai:doaj.org-article:16e2e698795e43da90d8453292c53ea7
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spelling	oai:doaj.org-article:16e2e698795e43da90d8453292c53ea72021-11-25T18:41:32ZBacterial Ghosts-Based Vaccine and Drug Delivery Systems10.3390/pharmaceutics131118921999-4923https://doaj.org/article/16e2e698795e43da90d8453292c53ea72021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1892https://doaj.org/toc/1999-4923Bacterial ghosts (BGs) are empty bacterial envelopes of Gram-negative bacteria produced by controlled expressions of cloned gene E, forming a lysis tunnel structure within the envelope of the living bacteria. Globally, BGs have been used as vaccine delivery systems and vaccine adjuvants. There is an increasing interest in the development of novel delivery systems that are based on BGs for biomedical applications. Due to intact reservation of bacterial cell membranes, BGs have an inherent immunogenicity, which enables targeted drug delivery and controlled release. As carrier vehicles, BGs protect drugs from interference by external factors. In recent years, there has been an increasing interest in BG-based delivery systems against tumors, inflammation, and infection, among others. Herein, we reviewed the preparation methods for BGs, interactions between BGs and the host, and further highlighted research progress in BG development.Haojie ChenHao JiXiangjun KongPengyu LeiQinsi YangWei WuLibo JinDa SunMDPI AGarticlebacterial ghostsgene Evaccinesimmunedelivery systemPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1892, p 1892 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial ghosts gene E vaccines immune delivery system Pharmacy and materia medica RS1-441
spellingShingle	bacterial ghosts gene E vaccines immune delivery system Pharmacy and materia medica RS1-441 Haojie Chen Hao Ji Xiangjun Kong Pengyu Lei Qinsi Yang Wei Wu Libo Jin Da Sun Bacterial Ghosts-Based Vaccine and Drug Delivery Systems
description	Bacterial ghosts (BGs) are empty bacterial envelopes of Gram-negative bacteria produced by controlled expressions of cloned gene E, forming a lysis tunnel structure within the envelope of the living bacteria. Globally, BGs have been used as vaccine delivery systems and vaccine adjuvants. There is an increasing interest in the development of novel delivery systems that are based on BGs for biomedical applications. Due to intact reservation of bacterial cell membranes, BGs have an inherent immunogenicity, which enables targeted drug delivery and controlled release. As carrier vehicles, BGs protect drugs from interference by external factors. In recent years, there has been an increasing interest in BG-based delivery systems against tumors, inflammation, and infection, among others. Herein, we reviewed the preparation methods for BGs, interactions between BGs and the host, and further highlighted research progress in BG development.
format	article
author	Haojie Chen Hao Ji Xiangjun Kong Pengyu Lei Qinsi Yang Wei Wu Libo Jin Da Sun
author_facet	Haojie Chen Hao Ji Xiangjun Kong Pengyu Lei Qinsi Yang Wei Wu Libo Jin Da Sun
author_sort	Haojie Chen
title	Bacterial Ghosts-Based Vaccine and Drug Delivery Systems
title_short	Bacterial Ghosts-Based Vaccine and Drug Delivery Systems
title_full	Bacterial Ghosts-Based Vaccine and Drug Delivery Systems
title_fullStr	Bacterial Ghosts-Based Vaccine and Drug Delivery Systems
title_full_unstemmed	Bacterial Ghosts-Based Vaccine and Drug Delivery Systems
title_sort	bacterial ghosts-based vaccine and drug delivery systems
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/16e2e698795e43da90d8453292c53ea7
work_keys_str_mv	AT haojiechen bacterialghostsbasedvaccineanddrugdeliverysystems AT haoji bacterialghostsbasedvaccineanddrugdeliverysystems AT xiangjunkong bacterialghostsbasedvaccineanddrugdeliverysystems AT pengyulei bacterialghostsbasedvaccineanddrugdeliverysystems AT qinsiyang bacterialghostsbasedvaccineanddrugdeliverysystems AT weiwu bacterialghostsbasedvaccineanddrugdeliverysystems AT libojin bacterialghostsbasedvaccineanddrugdeliverysystems AT dasun bacterialghostsbasedvaccineanddrugdeliverysystems
_version_	1718410757441323008

Bacterial Ghosts-Based Vaccine and Drug Delivery Systems

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