Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons
Abstract The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects. We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis...
Guardado en:
Autores principales: | Laurie Verzeaux, Nicolas Belloy, Jessica Thevenard-Devy, Jérôme Devy, Géraldine Ferracci, Laurent Martiny, Stéphane Dedieu, Manuel Dauchez, Hervé Emonard, Nicolas Etique, Emmanuelle Devarenne-Charpentier |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/16e3c09a1b4d4103a912523a3d0bd5d9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells
por: Elisabete Cruz Da Silva, et al.
Publicado: (2021) -
Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.
por: Katia Cortese, et al.
Publicado: (2008) -
Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2
por: Manuel Johanns, et al.
Publicado: (2017) -
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors
por: Kevin Boyé, et al.
Publicado: (2017) -
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis.
por: Marie-Florence Galliano, et al.
Publicado: (2008)