Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Inflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR...

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Autores principales:	Wenyuan Ma, Changmeng Cui, Song Feng, Genhua Li, Guangkui Han, Jilan Liu, Xianyun Qin, Yawei Hu, Mengjie Wang, Lu Zhang, Feng Jin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	moyamoya disease inflammation association platelet-to-lymphocyte ratio neutrophil-to-lymphocyte ratio Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/16e4a285d45c458eb600e2ba79261e59
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spelling	oai:doaj.org-article:16e4a285d45c458eb600e2ba79261e592021-11-10T05:39:19ZPlatelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study1664-229510.3389/fneur.2021.631454https://doaj.org/article/16e4a285d45c458eb600e2ba79261e592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.631454/fullhttps://doaj.org/toc/1664-2295Inflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR in patients with MMD is limited. The focus of this subject was to explore the relationship between PLR and NLR in patients with newly diagnosed MMD.Patients and methods: A cross-sectional study was performed including 261 patients with diagnosed MMD for the first time who were enrolled from our hospital, from 24 March 2013 to 24 December 2018. The clinical characteristics were collected for each patient. Univariate analysis, smooth curve fitting and multivariate piecewise linear regression were showed.Results: The mean levels or median values (interquartile range) of PLR and NLR were 146.979 ± 51.203 and 2.241 (1.589–2.984), respectively. A significant positive correlation between PLR and NLR levels (P < 0.001) was showed by the univariate analysis. Furthermore, a non-linear relationship was detected between PLR and NLR by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant positive correlation between PLR and NLR when the PLR level was lower than 219.82 (β 0.012, 95% CI 0.005, 0.019; P = 0.001). PLR was also significantly positively associated with NLR when PLR concentrations were >219.82 (β 0.098, 95% CI 0.069, 0.128; P < 0.001).Conclusion: There seemed to be a positive association between PLR and NLR in patients with MMD. This may help to further explain the role of inflammation in the occurrence and progress of MMD.Wenyuan MaChangmeng CuiSong FengGenhua LiGuangkui HanJilan LiuXianyun QinYawei HuMengjie WangLu ZhangFeng JinFrontiers Media S.A.articlemoyamoya diseaseinflammationassociationplatelet-to-lymphocyte rationeutrophil-to-lymphocyte ratioNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	moyamoya disease inflammation association platelet-to-lymphocyte ratio neutrophil-to-lymphocyte ratio Neurology. Diseases of the nervous system RC346-429
spellingShingle	moyamoya disease inflammation association platelet-to-lymphocyte ratio neutrophil-to-lymphocyte ratio Neurology. Diseases of the nervous system RC346-429 Wenyuan Ma Changmeng Cui Song Feng Genhua Li Guangkui Han Jilan Liu Xianyun Qin Yawei Hu Mengjie Wang Lu Zhang Feng Jin Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
description	Inflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR in patients with MMD is limited. The focus of this subject was to explore the relationship between PLR and NLR in patients with newly diagnosed MMD.Patients and methods: A cross-sectional study was performed including 261 patients with diagnosed MMD for the first time who were enrolled from our hospital, from 24 March 2013 to 24 December 2018. The clinical characteristics were collected for each patient. Univariate analysis, smooth curve fitting and multivariate piecewise linear regression were showed.Results: The mean levels or median values (interquartile range) of PLR and NLR were 146.979 ± 51.203 and 2.241 (1.589–2.984), respectively. A significant positive correlation between PLR and NLR levels (P < 0.001) was showed by the univariate analysis. Furthermore, a non-linear relationship was detected between PLR and NLR by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant positive correlation between PLR and NLR when the PLR level was lower than 219.82 (β 0.012, 95% CI 0.005, 0.019; P = 0.001). PLR was also significantly positively associated with NLR when PLR concentrations were >219.82 (β 0.098, 95% CI 0.069, 0.128; P < 0.001).Conclusion: There seemed to be a positive association between PLR and NLR in patients with MMD. This may help to further explain the role of inflammation in the occurrence and progress of MMD.
format	article
author	Wenyuan Ma Changmeng Cui Song Feng Genhua Li Guangkui Han Jilan Liu Xianyun Qin Yawei Hu Mengjie Wang Lu Zhang Feng Jin
author_facet	Wenyuan Ma Changmeng Cui Song Feng Genhua Li Guangkui Han Jilan Liu Xianyun Qin Yawei Hu Mengjie Wang Lu Zhang Feng Jin
author_sort	Wenyuan Ma
title	Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
title_short	Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
title_full	Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
title_fullStr	Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
title_full_unstemmed	Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
title_sort	platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with newly diagnosed moyamoya disease: a cross-sectional study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/16e4a285d45c458eb600e2ba79261e59
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Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

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