Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

The engagement of DNA-binding drugs to their target is difficult to study, particularly in vivo. Here the authors develop an in vivo fluorescence lifetime imaging confocal laparo/endomicroscope to show intra- and inter-tumor heterogeneity in doxorubicin binding to peritoneal metastases, which depend...

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Autores principales:	Hugh Sparks, Hiroshi Kondo, Steven Hooper, Ian Munro, Gordon Kennedy, Christopher Dunsby, Paul French, Erik Sahai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16e61afbf46944128bb69a5005d1648a
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spelling	oai:doaj.org-article:16e61afbf46944128bb69a5005d1648a2021-12-02T17:31:57ZHeterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy10.1038/s41467-018-04820-62041-1723https://doaj.org/article/16e61afbf46944128bb69a5005d1648a2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04820-6https://doaj.org/toc/2041-1723The engagement of DNA-binding drugs to their target is difficult to study, particularly in vivo. Here the authors develop an in vivo fluorescence lifetime imaging confocal laparo/endomicroscope to show intra- and inter-tumor heterogeneity in doxorubicin binding to peritoneal metastases, which depends on the route of administration.Hugh SparksHiroshi KondoSteven HooperIan MunroGordon KennedyChristopher DunsbyPaul FrenchErik SahaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hugh Sparks Hiroshi Kondo Steven Hooper Ian Munro Gordon Kennedy Christopher Dunsby Paul French Erik Sahai Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
description	The engagement of DNA-binding drugs to their target is difficult to study, particularly in vivo. Here the authors develop an in vivo fluorescence lifetime imaging confocal laparo/endomicroscope to show intra- and inter-tumor heterogeneity in doxorubicin binding to peritoneal metastases, which depends on the route of administration.
format	article
author	Hugh Sparks Hiroshi Kondo Steven Hooper Ian Munro Gordon Kennedy Christopher Dunsby Paul French Erik Sahai
author_facet	Hugh Sparks Hiroshi Kondo Steven Hooper Ian Munro Gordon Kennedy Christopher Dunsby Paul French Erik Sahai
author_sort	Hugh Sparks
title	Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
title_short	Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
title_full	Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
title_fullStr	Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
title_full_unstemmed	Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
title_sort	heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/16e61afbf46944128bb69a5005d1648a
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Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

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