Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

Background: Decidualization of the uterine mucosa drives the maternal adaptation to invasion by the placenta. Appropriate depth of placental invasion is needed to support a healthy pregnancy; shallow invasion is associated with the development of severe preeclampsia (sPE). Maternal contribution to s...

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Autores principales: Tamara Garrido-Gomez, Nerea Castillo-Marco, Mónica Clemente-Ciscar, Teresa Cordero, Irene Muñoz-Blat, Alicia Amadoz, Jorge Jimenez-Almazan, Rogelio Monfort-Ortiz, Reyes Climent, Alfredo Perales-Marin, Carlos Simon
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
Preeclampsia
human endometrium
decidua
defective decidualization
transcriptomic fingerprint
hormonal receptor
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/16e7af94886c455dba3d9bf58f47abf0
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https://doaj.org/article/16e7af94886c455dba3d9bf58f47abf0

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