<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance

Nowadays, research on bacteriophage therapy and its potential use in combination with antibiotics has been gaining momentum. One hundred and ten oral <i>Staphylococcus aureus</i> isolates were phage-typed and their antibiotic resistance was determined by standard and molecular methods. T...

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Autores principales:	Katarzyna Garbacz, Ewa Kwapisz, Lidia Piechowicz, Maria Wierzbowska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bacteriophage phage therapy <i>Staphylococcus aureus</i> oral cavity antibiotic resistance MRSA Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/16ea4c397ca24dee9cf78e5d46a5f7c4
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spelling	oai:doaj.org-article:16ea4c397ca24dee9cf78e5d46a5f7c42021-11-25T16:22:56Z<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance10.3390/antibiotics101113292079-6382https://doaj.org/article/16ea4c397ca24dee9cf78e5d46a5f7c42021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1329https://doaj.org/toc/2079-6382Nowadays, research on bacteriophage therapy and its potential use in combination with antibiotics has been gaining momentum. One hundred and ten oral <i>Staphylococcus aureus</i> isolates were phage-typed and their antibiotic resistance was determined by standard and molecular methods. The prevalence of MSSA and MRSA strains was 89.1% and 10.9%, respectively. Nearly all (91.8%) analyzed isolates, whether MSSA or MRSA, were susceptible to the phages used from the international set. The highest lytic activity showed phages 79 and 52 A from lytic group I. The predominant phage groups were mixed, the I+III group and a mixed group containing phages from at least three various lytic groups. <i>S. aureus</i> strains sensitive to phage group I were usually resistant to penicillin and susceptible to ciprofloxacin, whereas the strains typeable with group V or group V with the 95 phage were susceptible to most antibiotics. Epidemic CA-MRSA strains (SCC<i>mec</i>IV) of phage type 80/81 carried Panton–Valentine leucocidin genes. Considering the high sensitivity of oral <i>S. aureus</i> to the analyzed phages and the promising results of phage therapies reported by other authors, phage cocktails or phage-antibiotic combinations may potentially find applications in both the prevention and eradication of staphylococcal infections.Katarzyna GarbaczEwa KwapiszLidia PiechowiczMaria WierzbowskaMDPI AGarticlebacteriophagephage therapy<i>Staphylococcus aureus</i>oral cavityantibiotic resistanceMRSATherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1329, p 1329 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteriophage phage therapy <i>Staphylococcus aureus</i> oral cavity antibiotic resistance MRSA Therapeutics. Pharmacology RM1-950
spellingShingle	bacteriophage phage therapy <i>Staphylococcus aureus</i> oral cavity antibiotic resistance MRSA Therapeutics. Pharmacology RM1-950 Katarzyna Garbacz Ewa Kwapisz Lidia Piechowicz Maria Wierzbowska <i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance
description	Nowadays, research on bacteriophage therapy and its potential use in combination with antibiotics has been gaining momentum. One hundred and ten oral <i>Staphylococcus aureus</i> isolates were phage-typed and their antibiotic resistance was determined by standard and molecular methods. The prevalence of MSSA and MRSA strains was 89.1% and 10.9%, respectively. Nearly all (91.8%) analyzed isolates, whether MSSA or MRSA, were susceptible to the phages used from the international set. The highest lytic activity showed phages 79 and 52 A from lytic group I. The predominant phage groups were mixed, the I+III group and a mixed group containing phages from at least three various lytic groups. <i>S. aureus</i> strains sensitive to phage group I were usually resistant to penicillin and susceptible to ciprofloxacin, whereas the strains typeable with group V or group V with the 95 phage were susceptible to most antibiotics. Epidemic CA-MRSA strains (SCC<i>mec</i>IV) of phage type 80/81 carried Panton–Valentine leucocidin genes. Considering the high sensitivity of oral <i>S. aureus</i> to the analyzed phages and the promising results of phage therapies reported by other authors, phage cocktails or phage-antibiotic combinations may potentially find applications in both the prevention and eradication of staphylococcal infections.
format	article
author	Katarzyna Garbacz Ewa Kwapisz Lidia Piechowicz Maria Wierzbowska
author_facet	Katarzyna Garbacz Ewa Kwapisz Lidia Piechowicz Maria Wierzbowska
author_sort	Katarzyna Garbacz
title	<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance
title_short	<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance
title_full	<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance
title_fullStr	<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance
title_full_unstemmed	<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance
title_sort	<i>staphylococcus aureus</i> isolated from the oral cavity: phage susceptibility in relation to antibiotic resistance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/16ea4c397ca24dee9cf78e5d46a5f7c4
work_keys_str_mv	AT katarzynagarbacz istaphylococcusaureusiisolatedfromtheoralcavityphagesusceptibilityinrelationtoantibioticresistance AT ewakwapisz istaphylococcusaureusiisolatedfromtheoralcavityphagesusceptibilityinrelationtoantibioticresistance AT lidiapiechowicz istaphylococcusaureusiisolatedfromtheoralcavityphagesusceptibilityinrelationtoantibioticresistance AT mariawierzbowska istaphylococcusaureusiisolatedfromtheoralcavityphagesusceptibilityinrelationtoantibioticresistance
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<i>Staphylococcus aureus</i> Isolated from the Oral Cavity: Phage Susceptibility in Relation to Antibiotic Resistance

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