Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.

<h4>Background</h4>Excision repair cross-complimentary group 1 (ERCC1) is an essential component of the nucleotide excision repair system that is responsible for repairing damaged DNA. Functional genetic variations in the ERCC1 gene may alter DNA repair capacity and modulate cancer risk....

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Autores principales:	Jinhong Zhu, Rui-Xi Hua, Jing Jiang, Li-Qin Zhao, Xiuwei Sun, Jinwei Luan, Yaoguo Lang, Yanqi Sun, Kun Shang, Shiyun Peng, Jianqun Ma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16f195e9be454846bcea9d735e5f96a9
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spelling	oai:doaj.org-article:16f195e9be454846bcea9d735e5f96a92021-11-18T08:18:47ZAssociation studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0097616https://doaj.org/article/16f195e9be454846bcea9d735e5f96a92014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24841208/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Excision repair cross-complimentary group 1 (ERCC1) is an essential component of the nucleotide excision repair system that is responsible for repairing damaged DNA. Functional genetic variations in the ERCC1 gene may alter DNA repair capacity and modulate cancer risk. The putative roles of ERCC1 gene polymorphisms in lung cancer susceptibility have been widely investigated. However, the results remain controversial.<h4>Objectives</h4>An updated meta-analysis was conducted to explore whether lung cancer risk could be attributed to the following ERCC1 polymorphisms: rs11615 (T>C), rs3212986 (C>A), rs3212961 (A>C), rs3212948 (G>C), rs2298881 (C>A).<h4>Methods</h4>Several major databases (MEDLINE, EMBASE and Scopus) and the Chinese Biomedical database were searched for eligible studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of associations.<h4>Results</h4>Sixteen studies with 10,106 cases and 13,238 controls were included in this meta-analysis. Pooled ORs from 11 eligible studies (8,215 cases vs. 11,402 controls) suggested a significant association of ERCC1 rs11615 with increased risk for lung cancer (homozygous: CC versus TT, OR = 1.24, 95% CI: 1.04-1.48, P = 0.02). However, such an association was disproportionately driven by a single study. Removal of that study led to null association. Moreover, initial analyses suggested that ERCC1 rs11615 exerts a more profound effect on the susceptibility of non-smokers to lung cancer than that of smokers. Moreover, no statistically significant association was found between remaining ERCC1 polymorphisms of interest and lung cancer risk, except for rs3212948 variation (heterozygous: CG vs.GG, OR = 0.78, 95% CI: 0.67-0.90, P = 0.001; dominant: CG/CC vs.GG, OR = 0.79, 95% CI: 0.69-0.91, P = 0.001).<h4>Conclusion</h4>Overall, this meta-analysis suggests that ERCC1 rs3212948 G>C, but not others, is a lung cancer risk-associated polymorphism. Carefully designed studies with large sample size involving different ethnicity, smoking status, and cancer types are needed to validate these findings.Jinhong ZhuRui-Xi HuaJing JiangLi-Qin ZhaoXiuwei SunJinwei LuanYaoguo LangYanqi SunKun ShangShiyun PengJianqun MaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97616 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinhong Zhu Rui-Xi Hua Jing Jiang Li-Qin Zhao Xiuwei Sun Jinwei Luan Yaoguo Lang Yanqi Sun Kun Shang Shiyun Peng Jianqun Ma Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
description	<h4>Background</h4>Excision repair cross-complimentary group 1 (ERCC1) is an essential component of the nucleotide excision repair system that is responsible for repairing damaged DNA. Functional genetic variations in the ERCC1 gene may alter DNA repair capacity and modulate cancer risk. The putative roles of ERCC1 gene polymorphisms in lung cancer susceptibility have been widely investigated. However, the results remain controversial.<h4>Objectives</h4>An updated meta-analysis was conducted to explore whether lung cancer risk could be attributed to the following ERCC1 polymorphisms: rs11615 (T>C), rs3212986 (C>A), rs3212961 (A>C), rs3212948 (G>C), rs2298881 (C>A).<h4>Methods</h4>Several major databases (MEDLINE, EMBASE and Scopus) and the Chinese Biomedical database were searched for eligible studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of associations.<h4>Results</h4>Sixteen studies with 10,106 cases and 13,238 controls were included in this meta-analysis. Pooled ORs from 11 eligible studies (8,215 cases vs. 11,402 controls) suggested a significant association of ERCC1 rs11615 with increased risk for lung cancer (homozygous: CC versus TT, OR = 1.24, 95% CI: 1.04-1.48, P = 0.02). However, such an association was disproportionately driven by a single study. Removal of that study led to null association. Moreover, initial analyses suggested that ERCC1 rs11615 exerts a more profound effect on the susceptibility of non-smokers to lung cancer than that of smokers. Moreover, no statistically significant association was found between remaining ERCC1 polymorphisms of interest and lung cancer risk, except for rs3212948 variation (heterozygous: CG vs.GG, OR = 0.78, 95% CI: 0.67-0.90, P = 0.001; dominant: CG/CC vs.GG, OR = 0.79, 95% CI: 0.69-0.91, P = 0.001).<h4>Conclusion</h4>Overall, this meta-analysis suggests that ERCC1 rs3212948 G>C, but not others, is a lung cancer risk-associated polymorphism. Carefully designed studies with large sample size involving different ethnicity, smoking status, and cancer types are needed to validate these findings.
format	article
author	Jinhong Zhu Rui-Xi Hua Jing Jiang Li-Qin Zhao Xiuwei Sun Jinwei Luan Yaoguo Lang Yanqi Sun Kun Shang Shiyun Peng Jianqun Ma
author_facet	Jinhong Zhu Rui-Xi Hua Jing Jiang Li-Qin Zhao Xiuwei Sun Jinwei Luan Yaoguo Lang Yanqi Sun Kun Shang Shiyun Peng Jianqun Ma
author_sort	Jinhong Zhu
title	Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
title_short	Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
title_full	Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
title_fullStr	Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
title_full_unstemmed	Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
title_sort	association studies of ercc1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/16f195e9be454846bcea9d735e5f96a9
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Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis.

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