Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients

Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Un...

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Autores principales:	Novick D, Montgomery W, Aguado J, Peng XM, Haro JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Depression anxiety Asia observational outcomes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/16f1b2e52b314808bd30af1d6b43360a
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spelling	oai:doaj.org-article:16f1b2e52b314808bd30af1d6b43360a2021-12-02T01:55:07ZImpact of anxiety symptoms on outcomes of depression: an observational study in Asian patients1178-2021https://doaj.org/article/16f1b2e52b314808bd30af1d6b43360a2016-04-01T00:00:00Zhttps://www.dovepress.com/impact-of-anxiety-symptoms-on-outcomes-of-depression-an-observational--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Indianapolis, IN, USA Objective: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). Methods: The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. Results: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723–0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045–0.001]). Conclusion: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression. Keywords: depression, anxiety, Asia, observational, outcomesNovick DMontgomery WAguado JPeng XMHaro JMDove Medical PressarticleDepressionanxietyAsiaobservationaloutcomesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 795-800 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression anxiety Asia observational outcomes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Depression anxiety Asia observational outcomes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Novick D Montgomery W Aguado J Peng XM Haro JM Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
description	Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Indianapolis, IN, USA Objective: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). Methods: The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. Results: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723–0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045–0.001]). Conclusion: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression. Keywords: depression, anxiety, Asia, observational, outcomes
format	article
author	Novick D Montgomery W Aguado J Peng XM Haro JM
author_facet	Novick D Montgomery W Aguado J Peng XM Haro JM
author_sort	Novick D
title	Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
title_short	Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
title_full	Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
title_fullStr	Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
title_full_unstemmed	Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
title_sort	impact of anxiety symptoms on outcomes of depression: an observational study in asian patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/16f1b2e52b314808bd30af1d6b43360a
work_keys_str_mv	AT novickd impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT montgomeryw impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT aguadoj impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT pengxm impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT harojm impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients
_version_	1718402758828097536

Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients

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