Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles

Shijie Li,1 Daqi Zhang,1 Shihou Sheng,2 Hui Sun1 1Department of Thyroid Surgery, 2Department of Gastrointestinal Colorectal and Anal Surgery, China–Japan Union Hospital of Jilin University, Chang Chun, People’s Republic of China Abstract: Currently, therapy for thyroid cancer m...

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Autores principales:	Li SJ, Zhang DQ, Sheng SH, Sun H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Thyroid cancer silicon dioxide nanoparticle doxorubicin acid-triggered release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/16f206a7f90244dfb1b9267df60e63ed
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spelling	oai:doaj.org-article:16f206a7f90244dfb1b9267df60e63ed2021-12-02T06:33:30ZTargeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles1178-2013https://doaj.org/article/16f206a7f90244dfb1b9267df60e63ed2017-08-01T00:00:00Zhttps://www.dovepress.com/targeting-thyroid-cancer-with-acid-triggered-release-of-doxorubicin-fr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shijie Li,1 Daqi Zhang,1 Shihou Sheng,2 Hui Sun1 1Department of Thyroid Surgery, 2Department of Gastrointestinal Colorectal and Anal Surgery, China–Japan Union Hospital of Jilin University, Chang Chun, People’s Republic of China Abstract: Currently, therapy for thyroid cancer mainly involves surgery and radioiodine therapy. However, chemotherapy can be used in advanced and aggressive thyroid cancer that cannot be treated by other options. Nevertheless, a major obstacle to the successful treatment of thyroid cancer is the delivery of drugs to the thyroid gland. Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid–stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer. Doxorubicin nanoparticles can be triggered by acid to release the drug payload for cancer therapy. These nanoparticles shrink the tumor size in vivo with less toxic side effects. This research paves the way toward effective chemotherapy for thyroid cancer. Keywords: thyroid cancer, silicon dioxide nanoparticle, doxorubicin, acid-triggered releaseLi SJZhang DQSheng SHSun HDove Medical PressarticleThyroid cancersilicon dioxide nanoparticledoxorubicinacid-triggered releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5993-6003 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Thyroid cancer silicon dioxide nanoparticle doxorubicin acid-triggered release Medicine (General) R5-920
spellingShingle	Thyroid cancer silicon dioxide nanoparticle doxorubicin acid-triggered release Medicine (General) R5-920 Li SJ Zhang DQ Sheng SH Sun H Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
description	Shijie Li,1 Daqi Zhang,1 Shihou Sheng,2 Hui Sun1 1Department of Thyroid Surgery, 2Department of Gastrointestinal Colorectal and Anal Surgery, China–Japan Union Hospital of Jilin University, Chang Chun, People’s Republic of China Abstract: Currently, therapy for thyroid cancer mainly involves surgery and radioiodine therapy. However, chemotherapy can be used in advanced and aggressive thyroid cancer that cannot be treated by other options. Nevertheless, a major obstacle to the successful treatment of thyroid cancer is the delivery of drugs to the thyroid gland. Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid–stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer. Doxorubicin nanoparticles can be triggered by acid to release the drug payload for cancer therapy. These nanoparticles shrink the tumor size in vivo with less toxic side effects. This research paves the way toward effective chemotherapy for thyroid cancer. Keywords: thyroid cancer, silicon dioxide nanoparticle, doxorubicin, acid-triggered release
format	article
author	Li SJ Zhang DQ Sheng SH Sun H
author_facet	Li SJ Zhang DQ Sheng SH Sun H
author_sort	Li SJ
title	Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
title_short	Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
title_full	Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
title_fullStr	Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
title_full_unstemmed	Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
title_sort	targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/16f206a7f90244dfb1b9267df60e63ed
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_version_	1718399860255752192

Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles

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