SARS-CoV-2 infection and replication in human gastric organoids

Several clinical reports have described gastrointestinal symptoms for COVID-19, though whether the virus can replicate within the stomach remains unclear. Here the authors generate gastric organoids from human biopsies and show that the virus can efficiently infect gastric epithelium, suggesting tha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giovanni Giuseppe Giobbe, Francesco Bonfante, Brendan C. Jones, Onelia Gagliano, Camilla Luni, Elisa Zambaiti, Silvia Perin, Cecilia Laterza, Georg Busslinger, Hannah Stuart, Matteo Pagliari, Alessio Bortolami, Eva Mazzetto, Anna Manfredi, Chiara Colantuono, Lucio Di Filippo, Alessandro Filippo Pellegata, Valentina Panzarin, Nikhil Thapar, Vivian Sze Wing Li, Simon Eaton, Davide Cacchiarelli, Hans Clevers, Nicola Elvassore, Paolo De Coppi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16f8748d432646d085ed25fa4b80e5ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16f8748d432646d085ed25fa4b80e5ce
record_format	dspace
spelling	oai:doaj.org-article:16f8748d432646d085ed25fa4b80e5ce2021-11-21T12:34:32ZSARS-CoV-2 infection and replication in human gastric organoids10.1038/s41467-021-26762-22041-1723https://doaj.org/article/16f8748d432646d085ed25fa4b80e5ce2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26762-2https://doaj.org/toc/2041-1723Several clinical reports have described gastrointestinal symptoms for COVID-19, though whether the virus can replicate within the stomach remains unclear. Here the authors generate gastric organoids from human biopsies and show that the virus can efficiently infect gastric epithelium, suggesting that the stomach might have an active role in fecal-oral transmission.Giovanni Giuseppe GiobbeFrancesco BonfanteBrendan C. JonesOnelia GaglianoCamilla LuniElisa ZambaitiSilvia PerinCecilia LaterzaGeorg BusslingerHannah StuartMatteo PagliariAlessio BortolamiEva MazzettoAnna ManfrediChiara ColantuonoLucio Di FilippoAlessandro Filippo PellegataValentina PanzarinNikhil ThaparVivian Sze Wing LiSimon EatonDavide CacchiarelliHans CleversNicola ElvassorePaolo De CoppiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giovanni Giuseppe Giobbe Francesco Bonfante Brendan C. Jones Onelia Gagliano Camilla Luni Elisa Zambaiti Silvia Perin Cecilia Laterza Georg Busslinger Hannah Stuart Matteo Pagliari Alessio Bortolami Eva Mazzetto Anna Manfredi Chiara Colantuono Lucio Di Filippo Alessandro Filippo Pellegata Valentina Panzarin Nikhil Thapar Vivian Sze Wing Li Simon Eaton Davide Cacchiarelli Hans Clevers Nicola Elvassore Paolo De Coppi SARS-CoV-2 infection and replication in human gastric organoids
description	Several clinical reports have described gastrointestinal symptoms for COVID-19, though whether the virus can replicate within the stomach remains unclear. Here the authors generate gastric organoids from human biopsies and show that the virus can efficiently infect gastric epithelium, suggesting that the stomach might have an active role in fecal-oral transmission.
format	article
author	Giovanni Giuseppe Giobbe Francesco Bonfante Brendan C. Jones Onelia Gagliano Camilla Luni Elisa Zambaiti Silvia Perin Cecilia Laterza Georg Busslinger Hannah Stuart Matteo Pagliari Alessio Bortolami Eva Mazzetto Anna Manfredi Chiara Colantuono Lucio Di Filippo Alessandro Filippo Pellegata Valentina Panzarin Nikhil Thapar Vivian Sze Wing Li Simon Eaton Davide Cacchiarelli Hans Clevers Nicola Elvassore Paolo De Coppi
author_facet	Giovanni Giuseppe Giobbe Francesco Bonfante Brendan C. Jones Onelia Gagliano Camilla Luni Elisa Zambaiti Silvia Perin Cecilia Laterza Georg Busslinger Hannah Stuart Matteo Pagliari Alessio Bortolami Eva Mazzetto Anna Manfredi Chiara Colantuono Lucio Di Filippo Alessandro Filippo Pellegata Valentina Panzarin Nikhil Thapar Vivian Sze Wing Li Simon Eaton Davide Cacchiarelli Hans Clevers Nicola Elvassore Paolo De Coppi
author_sort	Giovanni Giuseppe Giobbe
title	SARS-CoV-2 infection and replication in human gastric organoids
title_short	SARS-CoV-2 infection and replication in human gastric organoids
title_full	SARS-CoV-2 infection and replication in human gastric organoids
title_fullStr	SARS-CoV-2 infection and replication in human gastric organoids
title_full_unstemmed	SARS-CoV-2 infection and replication in human gastric organoids
title_sort	sars-cov-2 infection and replication in human gastric organoids
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16f8748d432646d085ed25fa4b80e5ce
work_keys_str_mv	AT giovannigiuseppegiobbe sarscov2infectionandreplicationinhumangastricorganoids AT francescobonfante sarscov2infectionandreplicationinhumangastricorganoids AT brendancjones sarscov2infectionandreplicationinhumangastricorganoids AT oneliagagliano sarscov2infectionandreplicationinhumangastricorganoids AT camillaluni sarscov2infectionandreplicationinhumangastricorganoids AT elisazambaiti sarscov2infectionandreplicationinhumangastricorganoids AT silviaperin sarscov2infectionandreplicationinhumangastricorganoids AT cecilialaterza sarscov2infectionandreplicationinhumangastricorganoids AT georgbusslinger sarscov2infectionandreplicationinhumangastricorganoids AT hannahstuart sarscov2infectionandreplicationinhumangastricorganoids AT matteopagliari sarscov2infectionandreplicationinhumangastricorganoids AT alessiobortolami sarscov2infectionandreplicationinhumangastricorganoids AT evamazzetto sarscov2infectionandreplicationinhumangastricorganoids AT annamanfredi sarscov2infectionandreplicationinhumangastricorganoids AT chiaracolantuono sarscov2infectionandreplicationinhumangastricorganoids AT luciodifilippo sarscov2infectionandreplicationinhumangastricorganoids AT alessandrofilippopellegata sarscov2infectionandreplicationinhumangastricorganoids AT valentinapanzarin sarscov2infectionandreplicationinhumangastricorganoids AT nikhilthapar sarscov2infectionandreplicationinhumangastricorganoids AT vivianszewingli sarscov2infectionandreplicationinhumangastricorganoids AT simoneaton sarscov2infectionandreplicationinhumangastricorganoids AT davidecacchiarelli sarscov2infectionandreplicationinhumangastricorganoids AT hansclevers sarscov2infectionandreplicationinhumangastricorganoids AT nicolaelvassore sarscov2infectionandreplicationinhumangastricorganoids AT paolodecoppi sarscov2infectionandreplicationinhumangastricorganoids
_version_	1718418868462944256

SARS-CoV-2 infection and replication in human gastric organoids

Ejemplares similares