Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.

Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of a...

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Autores principales:	Christina Duftner, Rüdiger Seiler, Christian Dejaco, Iris Chemelli-Steingruber, Harald Schennach, Werner Klotz, Michael Rieger, Manfred Herold, Jürgen Falkensammer, Gustav Fraedrich, Michael Schirmer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16fbabfcda6c4e689a2364a88db66f39
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spelling	oai:doaj.org-article:16fbabfcda6c4e689a2364a88db66f392021-11-25T06:10:16ZAntiphospholipid antibodies predict progression of abdominal aortic aneurysms.1932-620310.1371/journal.pone.0099302https://doaj.org/article/16fbabfcda6c4e689a2364a88db66f392014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24979700/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of an intra-aneurysmal thrombus in abdominal aortic aneurysm (AAA) patients. APLs ELISAs were performed in frozen serum samples of 96 consecutive AAA patients and 48 healthy controls yielding positive test results in 13 patients (13.5%) and 3 controls (6.3%; n.s.). Nine of the 13 aPL-positive AAA patients underwent a second antibody testing >12 weeks apart revealing a positive result in 6 cases. APL-positive patients had increased levels of inflammatory markers compared to aPL-negative patients. Disease progression was defined as an increase of the AAA diameter >0.5 cm/year measured by sonography. Follow-up was performed in 69 patients identifying 41 (59.4%) patients with progressive disease. Performing multipredictor logistic regression analysis adjusting for classical AAA risk factors as confounders, the presence of aPLs at baseline revealed an odds ratio of 9.4 (95% CI 1.0-86.8, p = 0.049) to predict AAA progression. Fifty-five patients underwent a computed tomography in addition to ultrasound assessment indicating intra-aneurysmal thrombus formation in 82.3%. Median thrombus volume was 46.7 cm3 (1.9-377.5). AAA diameter correlated with the size of the intra-aneurysmal thrombus (corrcoeff = 0.721, p<0.001), however neither the presence nor the size of the intra-aneurysmal thrombus were related to the presence of aPLs. In conclusion, the presence of aPLs is associated with elevated levels of inflammatory markers and is an independent predictor of progressive disease in AAA patients.Christina DuftnerRüdiger SeilerChristian DejacoIris Chemelli-SteingruberHarald SchennachWerner KlotzMichael RiegerManfred HeroldJürgen FalkensammerGustav FraedrichMichael SchirmerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99302 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Duftner Rüdiger Seiler Christian Dejaco Iris Chemelli-Steingruber Harald Schennach Werner Klotz Michael Rieger Manfred Herold Jürgen Falkensammer Gustav Fraedrich Michael Schirmer Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
description	Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of an intra-aneurysmal thrombus in abdominal aortic aneurysm (AAA) patients. APLs ELISAs were performed in frozen serum samples of 96 consecutive AAA patients and 48 healthy controls yielding positive test results in 13 patients (13.5%) and 3 controls (6.3%; n.s.). Nine of the 13 aPL-positive AAA patients underwent a second antibody testing >12 weeks apart revealing a positive result in 6 cases. APL-positive patients had increased levels of inflammatory markers compared to aPL-negative patients. Disease progression was defined as an increase of the AAA diameter >0.5 cm/year measured by sonography. Follow-up was performed in 69 patients identifying 41 (59.4%) patients with progressive disease. Performing multipredictor logistic regression analysis adjusting for classical AAA risk factors as confounders, the presence of aPLs at baseline revealed an odds ratio of 9.4 (95% CI 1.0-86.8, p = 0.049) to predict AAA progression. Fifty-five patients underwent a computed tomography in addition to ultrasound assessment indicating intra-aneurysmal thrombus formation in 82.3%. Median thrombus volume was 46.7 cm3 (1.9-377.5). AAA diameter correlated with the size of the intra-aneurysmal thrombus (corrcoeff = 0.721, p<0.001), however neither the presence nor the size of the intra-aneurysmal thrombus were related to the presence of aPLs. In conclusion, the presence of aPLs is associated with elevated levels of inflammatory markers and is an independent predictor of progressive disease in AAA patients.
format	article
author	Christina Duftner Rüdiger Seiler Christian Dejaco Iris Chemelli-Steingruber Harald Schennach Werner Klotz Michael Rieger Manfred Herold Jürgen Falkensammer Gustav Fraedrich Michael Schirmer
author_facet	Christina Duftner Rüdiger Seiler Christian Dejaco Iris Chemelli-Steingruber Harald Schennach Werner Klotz Michael Rieger Manfred Herold Jürgen Falkensammer Gustav Fraedrich Michael Schirmer
author_sort	Christina Duftner
title	Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
title_short	Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
title_full	Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
title_fullStr	Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
title_full_unstemmed	Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
title_sort	antiphospholipid antibodies predict progression of abdominal aortic aneurysms.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/16fbabfcda6c4e689a2364a88db66f39
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Antiphospholipid antibodies predict progression of abdominal aortic aneurysms.

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