Interpretation of morphogen gradients by a synthetic bistable circuit

Morphogen gradients can be dynamic and transient yet give rise to stable cellular patterns. Here the authors show that a synthetic morphogen-induced mutual inhibition circuit produces stable boundaries when the spatial average of morphogens falls within the region of bistability.

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Bibliographic Details
Main Authors:	Paul K. Grant, Gregory Szep, Om Patange, Jacob Halatek, Valerie Coppard, Attila Csikász-Nagy, Jim Haseloff, James C. W. Locke, Neil Dalchau, Andrew Phillips
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/16fc968713644a57910ee1bc73fd0b96
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spelling	oai:doaj.org-article:16fc968713644a57910ee1bc73fd0b962021-12-02T15:39:22ZInterpretation of morphogen gradients by a synthetic bistable circuit10.1038/s41467-020-19098-w2041-1723https://doaj.org/article/16fc968713644a57910ee1bc73fd0b962020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19098-whttps://doaj.org/toc/2041-1723Morphogen gradients can be dynamic and transient yet give rise to stable cellular patterns. Here the authors show that a synthetic morphogen-induced mutual inhibition circuit produces stable boundaries when the spatial average of morphogens falls within the region of bistability.Paul K. GrantGregory SzepOm PatangeJacob HalatekValerie CoppardAttila Csikász-NagyJim HaseloffJames C. W. LockeNeil DalchauAndrew PhillipsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul K. Grant Gregory Szep Om Patange Jacob Halatek Valerie Coppard Attila Csikász-Nagy Jim Haseloff James C. W. Locke Neil Dalchau Andrew Phillips Interpretation of morphogen gradients by a synthetic bistable circuit
description	Morphogen gradients can be dynamic and transient yet give rise to stable cellular patterns. Here the authors show that a synthetic morphogen-induced mutual inhibition circuit produces stable boundaries when the spatial average of morphogens falls within the region of bistability.
format	article
author	Paul K. Grant Gregory Szep Om Patange Jacob Halatek Valerie Coppard Attila Csikász-Nagy Jim Haseloff James C. W. Locke Neil Dalchau Andrew Phillips
author_facet	Paul K. Grant Gregory Szep Om Patange Jacob Halatek Valerie Coppard Attila Csikász-Nagy Jim Haseloff James C. W. Locke Neil Dalchau Andrew Phillips
author_sort	Paul K. Grant
title	Interpretation of morphogen gradients by a synthetic bistable circuit
title_short	Interpretation of morphogen gradients by a synthetic bistable circuit
title_full	Interpretation of morphogen gradients by a synthetic bistable circuit
title_fullStr	Interpretation of morphogen gradients by a synthetic bistable circuit
title_full_unstemmed	Interpretation of morphogen gradients by a synthetic bistable circuit
title_sort	interpretation of morphogen gradients by a synthetic bistable circuit
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/16fc968713644a57910ee1bc73fd0b96
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Interpretation of morphogen gradients by a synthetic bistable circuit

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