Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia

Sirijit Suttajit, Sutrak PilakantaDepartment of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandPurpose: To identify the point prevalence of metabolic syndrome in patients with schizophrenia and to evaluate the association between depressive symptoms and metabolic syndrom...

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Autores principales:	Suttajit S, Pilakanta S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1705c7cf40224ce2b5c04f173eb73111
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spelling	oai:doaj.org-article:1705c7cf40224ce2b5c04f173eb731112021-12-02T09:53:16ZPrevalence of metabolic syndrome and its association with depression in patients with schizophrenia1176-63281178-2021https://doaj.org/article/1705c7cf40224ce2b5c04f173eb731112013-07-01T00:00:00Zhttp://www.dovepress.com/prevalence-of-metabolic-syndrome-and-its-association-with-depression-i-a13609https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Sirijit Suttajit, Sutrak PilakantaDepartment of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandPurpose: To identify the point prevalence of metabolic syndrome in patients with schizophrenia and to evaluate the association between depressive symptoms and metabolic syndrome in patients with schizophrenia.Patients and methods: Metabolic syndrome was assessed based on an updated definition derived from the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation criteria. The 17-item Hamilton Depression Rating Scale (HDRS-17) was used to measure depressive symptoms in 80 patients with schizophrenia. Odds ratios and 95% confidence intervals were calculated using logistic regression for the association between each depressive symptom and metabolic syndrome.Results: The point prevalence rates of metabolic syndrome according to the modified NCEP-ATP III and International Diabetes Federation criteria were 37% and 35%, respectively. The risk of having metabolic syndrome significantly increased in those who were widowed or separated, or had longer duration of illness. Central obesity was the metabolic feature with the highest odds ratios for metabolic syndrome at 19.3. Three out of 17 items of HDRS subscales were found to be significantly associated with metabolic syndrome, including depressed mood, middle insomnia, and retardation with the odds ratios of 3.0, 3.4, and 3.6, respectively.Conclusion: This study showed that the prevalence of metabolic syndrome in patients with schizophrenia was higher than the overall rate but was slightly lower than in the general population in the USA. Central obesity, measured by waist circumference, was found to be highly correlated with metabolic syndrome. Depressed mood, middle insomnia, and retardation were significantly associated with metabolic syndrome in patients with schizophrenia. Waist circumference and screening for depression should be done at the clinics during patient follow-up.Keywords: mood symptoms, hypertension, dyslipidemia, hyperglycemia, central obesitySuttajit SPilakanta SDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 941-946 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Suttajit S Pilakanta S Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
description	Sirijit Suttajit, Sutrak PilakantaDepartment of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandPurpose: To identify the point prevalence of metabolic syndrome in patients with schizophrenia and to evaluate the association between depressive symptoms and metabolic syndrome in patients with schizophrenia.Patients and methods: Metabolic syndrome was assessed based on an updated definition derived from the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation criteria. The 17-item Hamilton Depression Rating Scale (HDRS-17) was used to measure depressive symptoms in 80 patients with schizophrenia. Odds ratios and 95% confidence intervals were calculated using logistic regression for the association between each depressive symptom and metabolic syndrome.Results: The point prevalence rates of metabolic syndrome according to the modified NCEP-ATP III and International Diabetes Federation criteria were 37% and 35%, respectively. The risk of having metabolic syndrome significantly increased in those who were widowed or separated, or had longer duration of illness. Central obesity was the metabolic feature with the highest odds ratios for metabolic syndrome at 19.3. Three out of 17 items of HDRS subscales were found to be significantly associated with metabolic syndrome, including depressed mood, middle insomnia, and retardation with the odds ratios of 3.0, 3.4, and 3.6, respectively.Conclusion: This study showed that the prevalence of metabolic syndrome in patients with schizophrenia was higher than the overall rate but was slightly lower than in the general population in the USA. Central obesity, measured by waist circumference, was found to be highly correlated with metabolic syndrome. Depressed mood, middle insomnia, and retardation were significantly associated with metabolic syndrome in patients with schizophrenia. Waist circumference and screening for depression should be done at the clinics during patient follow-up.Keywords: mood symptoms, hypertension, dyslipidemia, hyperglycemia, central obesity
format	article
author	Suttajit S Pilakanta S
author_facet	Suttajit S Pilakanta S
author_sort	Suttajit S
title	Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
title_short	Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
title_full	Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
title_fullStr	Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
title_full_unstemmed	Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
title_sort	prevalence of metabolic syndrome and its association with depression in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/1705c7cf40224ce2b5c04f173eb73111
work_keys_str_mv	AT suttajits prevalenceofmetabolicsyndromeanditsassociationwithdepressioninpatientswithschizophrenia AT pilakantas prevalenceofmetabolicsyndromeanditsassociationwithdepressioninpatientswithschizophrenia
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Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia

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