Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients

Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katarzyna Beata Skórska, Sylwia Płaczkowska, Anna Prescha, Irena Porębska, Monika Kosacka, Konrad Pawełczyk, Katarzyna Zabłocka-Słowińska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung cancer SOD1 SOD2 serum total SOD activity Glasgow prognostic score Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/170718d36398407fb12010ec9a360493
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:170718d36398407fb12010ec9a360493
record_format	dspace
spelling	oai:doaj.org-article:170718d36398407fb12010ec9a3604932021-11-25T18:39:04ZSerum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients10.3390/ph141110671424-8247https://doaj.org/article/170718d36398407fb12010ec9a3604932021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1067https://doaj.org/toc/1424-8247Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has following aims: (1) to evaluate the disturbances in serum SOD activity and SOD1/2 concentrations; (2) to assess the implications of these alterations with regard to biochemical variables and clinical data, and (3) to investigate the association between serum SOD activity, SOD1/2 concentrations, and all-cause mortality in lung cancer patients. Serum total SOD activity and SOD1, SOD2, albumin, CRP, and ceruloplasmin concentrations were determined in lung cancer patients (n = 190) and control subjects (n = 52). Additionally, patients were characterized in terms of biochemical, clinical, and sociodemographic data. Multiple Cox regression models were used to estimate the association between all-cause death and SOD-related parameters. All-cause mortality in lung cancer was positively associated with serum SOD1 and SOD2 concentrations. Clinical stage III and IV disease was the strongest predictor. The utility of the evaluated parameters in predicting overall survival was demonstrated only for SOD1. Serum SOD1 and SOD2 concentrations were shown to positively affect all-cause mortality in lung cancer patients, but SOD1 seems to be a better predictor than SOD2.Katarzyna Beata SkórskaSylwia PłaczkowskaAnna PreschaIrena PorębskaMonika KosackaKonrad PawełczykKatarzyna Zabłocka-SłowińskaMDPI AGarticlelung cancerSOD1SOD2serumtotal SOD activityGlasgow prognostic scoreMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1067, p 1067 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer SOD1 SOD2 serum total SOD activity Glasgow prognostic score Medicine R Pharmacy and materia medica RS1-441
spellingShingle	lung cancer SOD1 SOD2 serum total SOD activity Glasgow prognostic score Medicine R Pharmacy and materia medica RS1-441 Katarzyna Beata Skórska Sylwia Płaczkowska Anna Prescha Irena Porębska Monika Kosacka Konrad Pawełczyk Katarzyna Zabłocka-Słowińska Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
description	Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has following aims: (1) to evaluate the disturbances in serum SOD activity and SOD1/2 concentrations; (2) to assess the implications of these alterations with regard to biochemical variables and clinical data, and (3) to investigate the association between serum SOD activity, SOD1/2 concentrations, and all-cause mortality in lung cancer patients. Serum total SOD activity and SOD1, SOD2, albumin, CRP, and ceruloplasmin concentrations were determined in lung cancer patients (n = 190) and control subjects (n = 52). Additionally, patients were characterized in terms of biochemical, clinical, and sociodemographic data. Multiple Cox regression models were used to estimate the association between all-cause death and SOD-related parameters. All-cause mortality in lung cancer was positively associated with serum SOD1 and SOD2 concentrations. Clinical stage III and IV disease was the strongest predictor. The utility of the evaluated parameters in predicting overall survival was demonstrated only for SOD1. Serum SOD1 and SOD2 concentrations were shown to positively affect all-cause mortality in lung cancer patients, but SOD1 seems to be a better predictor than SOD2.
format	article
author	Katarzyna Beata Skórska Sylwia Płaczkowska Anna Prescha Irena Porębska Monika Kosacka Konrad Pawełczyk Katarzyna Zabłocka-Słowińska
author_facet	Katarzyna Beata Skórska Sylwia Płaczkowska Anna Prescha Irena Porębska Monika Kosacka Konrad Pawełczyk Katarzyna Zabłocka-Słowińska
author_sort	Katarzyna Beata Skórska
title	Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_short	Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_full	Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_fullStr	Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_full_unstemmed	Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
title_sort	serum total sod activity and sod1/2 concentrations in predicting all-cause mortality in lung cancer patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/170718d36398407fb12010ec9a360493
work_keys_str_mv	AT katarzynabeataskorska serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients AT sylwiapłaczkowska serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients AT annaprescha serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients AT irenaporebska serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients AT monikakosacka serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients AT konradpawełczyk serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients AT katarzynazabłockasłowinska serumtotalsodactivityandsod12concentrationsinpredictingallcausemortalityinlungcancerpatients
_version_	1718410817732345856

Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients

Ejemplares similares