The use of preservatives in dry eye drops

Karen Walsh, Lyndon JonesCentre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, N2L 3G1, CanadaAbstract: Topical ocular preparations are widely recommended by health care professionals, or chosen by patients, to help manage dr...

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Autores principales:	Walsh K, Jones L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Dry eye disease preservatives benzalkonium chloride polyquaternium-1 preservative-free Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/170cc79b9fdc4481b583767b4699e7b9
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spelling	oai:doaj.org-article:170cc79b9fdc4481b583767b4699e7b92021-12-02T04:14:31ZThe use of preservatives in dry eye drops1177-5483https://doaj.org/article/170cc79b9fdc4481b583767b4699e7b92019-08-01T00:00:00Zhttps://www.dovepress.com/the-use-of-preservatives-in-dry-eye-drops-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Karen Walsh, Lyndon JonesCentre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, N2L 3G1, CanadaAbstract: Topical ocular preparations are widely recommended by health care professionals, or chosen by patients, to help manage dry eye disease (DED). The chronic and progressive nature of DED may result in the administration of topical products several times a day, over a period of many years. Given DED is a condition that by definition affects the ocular surface, it is important to understand how the repeated use of eye drops may impact the ocular surface, influence clinical signs, affect symptoms, and impact the overall disease process of dry eye. The component in topical preparations with the greatest potential to adversely affect the ocular surface is the preservative. This paper reviews the literature in relation to the use of preservatives in formulations for dry eye. The ocular effects of benzalkonium chloride (BAK) are summarised and compared to the performance of alternative preservatives and preservative-free formulations. Use of preserved and preservative-free drops in relation to the management of varying stages of DED is discussed.Keywords: dry eye disease, preservatives, benzalkonium chloride (BAK), polyquaternium-1 (PQ-1), preservative-freeWalsh KJones LDove Medical PressarticleDry eye diseasepreservativesbenzalkonium chloridepolyquaternium-1preservative-freeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1409-1425 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dry eye disease preservatives benzalkonium chloride polyquaternium-1 preservative-free Ophthalmology RE1-994
spellingShingle	Dry eye disease preservatives benzalkonium chloride polyquaternium-1 preservative-free Ophthalmology RE1-994 Walsh K Jones L The use of preservatives in dry eye drops
description	Karen Walsh, Lyndon JonesCentre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, N2L 3G1, CanadaAbstract: Topical ocular preparations are widely recommended by health care professionals, or chosen by patients, to help manage dry eye disease (DED). The chronic and progressive nature of DED may result in the administration of topical products several times a day, over a period of many years. Given DED is a condition that by definition affects the ocular surface, it is important to understand how the repeated use of eye drops may impact the ocular surface, influence clinical signs, affect symptoms, and impact the overall disease process of dry eye. The component in topical preparations with the greatest potential to adversely affect the ocular surface is the preservative. This paper reviews the literature in relation to the use of preservatives in formulations for dry eye. The ocular effects of benzalkonium chloride (BAK) are summarised and compared to the performance of alternative preservatives and preservative-free formulations. Use of preserved and preservative-free drops in relation to the management of varying stages of DED is discussed.Keywords: dry eye disease, preservatives, benzalkonium chloride (BAK), polyquaternium-1 (PQ-1), preservative-free
format	article
author	Walsh K Jones L
author_facet	Walsh K Jones L
author_sort	Walsh K
title	The use of preservatives in dry eye drops
title_short	The use of preservatives in dry eye drops
title_full	The use of preservatives in dry eye drops
title_fullStr	The use of preservatives in dry eye drops
title_full_unstemmed	The use of preservatives in dry eye drops
title_sort	use of preservatives in dry eye drops
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/170cc79b9fdc4481b583767b4699e7b9
work_keys_str_mv	AT walshk theuseofpreservativesindryeyedrops AT jonesl theuseofpreservativesindryeyedrops AT walshk useofpreservativesindryeyedrops AT jonesl useofpreservativesindryeyedrops
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The use of preservatives in dry eye drops

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