The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells

The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells

Cancer stem cells (CSCs) initiate tumor formation and are known to be resistant to chemotherapy. A metabolic alteration in CSCs plays a critical role in stemness and survival. However, the association between mitochondrial energy metabolism and the redox system remains undefined in colon CSCs. In th...

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Autores principales: In-Sung Song, Yu Jeong Jeong, Yena Jung, Young-Ho Park, Sungbo Shim, Sung Joo Kim, Dae-Woon Eom, Seung-Mo Hong, Peter C.W. Lee, Sun-Uk Kim, Sung-Wuk Jang
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Colon
Cancer stem cell
Sulfiredoxin
Peroxiredoxin
Stemness
ROS
Medicine (General)
R5-920
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/170ecf4e8064481e84374c2fee219475
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spelling oai:doaj.org-article:170ecf4e8064481e84374c2fee2194752021-11-18T04:48:24ZThe sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells2213-231710.1016/j.redox.2021.102190https://doaj.org/article/170ecf4e8064481e84374c2fee2194752021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213231721003505https://doaj.org/toc/2213-2317Cancer stem cells (CSCs) initiate tumor formation and are known to be resistant to chemotherapy. A metabolic alteration in CSCs plays a critical role in stemness and survival. However, the association between mitochondrial energy metabolism and the redox system remains undefined in colon CSCs. In this study, we assessed the role of the Sulfiredoxin-Peroxiredoxin (Srx-Prx) redox system and mitochondrial oxidative phosphorylation (OXPHOS) in maintaining the stemness and survival of colon CSCs. Notably, Srx contributed to the stability of PrxI, PrxII, and PrxIII proteins in colon CSCs. Increased Srx expression promoted the stemness and survival of CSCs and was important for the maintenance of the mitochondrial OXPHOS system. Furthermore, Nrf2 and FoxM1 led to OXPHOS activation and upregulated expression of Srx-Prx redox system-related genes. Therefore, the Nrf2/FoxM1-induced Srx-Prx redox system is a potential therapeutic target for eliminating CSCs in colon cancer.In-Sung SongYu Jeong JeongYena JungYoung-Ho ParkSungbo ShimSung Joo KimDae-Woon EomSeung-Mo HongPeter C.W. LeeSun-Uk KimSung-Wuk JangElsevierarticleColonCancer stem cellSulfiredoxinPeroxiredoxinStemnessROSMedicine (General)R5-920Biology (General)QH301-705.5ENRedox Biology, Vol 48, Iss , Pp 102190- (2021)
institution DOAJ
collection DOAJ
language EN
topic Colon
Cancer stem cell
Sulfiredoxin
Peroxiredoxin
Stemness
ROS
Medicine (General)
R5-920
Biology (General)
QH301-705.5
spellingShingle Colon
Cancer stem cell
Sulfiredoxin
Peroxiredoxin
Stemness
ROS
Medicine (General)
R5-920
Biology (General)
QH301-705.5
In-Sung Song
Yu Jeong Jeong
Yena Jung
Young-Ho Park
Sungbo Shim
Sung Joo Kim
Dae-Woon Eom
Seung-Mo Hong
Peter C.W. Lee
Sun-Uk Kim
Sung-Wuk Jang
The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
description Cancer stem cells (CSCs) initiate tumor formation and are known to be resistant to chemotherapy. A metabolic alteration in CSCs plays a critical role in stemness and survival. However, the association between mitochondrial energy metabolism and the redox system remains undefined in colon CSCs. In this study, we assessed the role of the Sulfiredoxin-Peroxiredoxin (Srx-Prx) redox system and mitochondrial oxidative phosphorylation (OXPHOS) in maintaining the stemness and survival of colon CSCs. Notably, Srx contributed to the stability of PrxI, PrxII, and PrxIII proteins in colon CSCs. Increased Srx expression promoted the stemness and survival of CSCs and was important for the maintenance of the mitochondrial OXPHOS system. Furthermore, Nrf2 and FoxM1 led to OXPHOS activation and upregulated expression of Srx-Prx redox system-related genes. Therefore, the Nrf2/FoxM1-induced Srx-Prx redox system is a potential therapeutic target for eliminating CSCs in colon cancer.
format article
author In-Sung Song
Yu Jeong Jeong
Yena Jung
Young-Ho Park
Sungbo Shim
Sung Joo Kim
Dae-Woon Eom
Seung-Mo Hong
Peter C.W. Lee
Sun-Uk Kim
Sung-Wuk Jang
author_facet In-Sung Song
Yu Jeong Jeong
Yena Jung
Young-Ho Park
Sungbo Shim
Sung Joo Kim
Dae-Woon Eom
Seung-Mo Hong
Peter C.W. Lee
Sun-Uk Kim
Sung-Wuk Jang
author_sort In-Sung Song
title The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
title_short The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
title_full The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
title_fullStr The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
title_full_unstemmed The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
title_sort sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells
publisher Elsevier
publishDate 2021
url https://doaj.org/article/170ecf4e8064481e84374c2fee219475
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