Understanding the Multiple Effects of PCBs on Lipid Metabolism

Qiuli Shan,1,2,* Hongmei Li,1,* Ningning Chen,1,* Fan Qu,1 Jing Guo1 1College of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China; 2State Key Laboratory of Environmental Chemistry and Eco-Toxicology, Research Center for Eco-Environmental Scie...

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Autores principales:	Shan Q, Li H, Chen N, Qu F, Guo J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pcbs metabolism-disrupting chemicals hepatocytes lipid metabolism Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/171214658aa74dda9026f3bcd676246c
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spelling	oai:doaj.org-article:171214658aa74dda9026f3bcd676246c2021-12-02T12:22:51ZUnderstanding the Multiple Effects of PCBs on Lipid Metabolism1178-7007https://doaj.org/article/171214658aa74dda9026f3bcd676246c2020-10-01T00:00:00Zhttps://www.dovepress.com/understanding-the-multiple-effects-of-pcbs-on-lipid-metabolism-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Qiuli Shan,1,2,* Hongmei Li,1,* Ningning Chen,1,* Fan Qu,1 Jing Guo1 1College of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China; 2State Key Laboratory of Environmental Chemistry and Eco-Toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiuli Shan Email bio_shanql@ujn.edu.cnAbstract: Polychlorinated biphenyls (PCBs) are a typical class of environmental contaminants recently shown to be metabolism-disrupting chemicals. Lipids are a highly complex group of biomolecules that not only form the structural basis of biofilms but also act as signaling molecules and energy sources. Lipid metabolic disorders contribute to multiple diseases, including obesity, diabetes, fatty liver, and metabolic syndromes. Although previous literature has reported that PCBs can affect lipid metabolism, including lipid synthesis, uptake, and elimination, few systematic summaries of the detailed process of lipid metabolism caused by PCB exposure have been published. Lipid metabolic processes involve many molecules; however, the key factors that are sensitive to PCB exposure have not been fully clarified. Here, we summarize the recent developments in PCB research with a focus on biomarkers of lipid metabolic disorders related to environmental exposures.Keywords: PCBs, metabolism-disrupting chemicals, hepatocytes, lipid metabolismShan QLi HChen NQu FGuo JDove Medical Pressarticlepcbsmetabolism-disrupting chemicalshepatocyteslipid metabolismSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3691-3702 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pcbs metabolism-disrupting chemicals hepatocytes lipid metabolism Specialties of internal medicine RC581-951
spellingShingle	pcbs metabolism-disrupting chemicals hepatocytes lipid metabolism Specialties of internal medicine RC581-951 Shan Q Li H Chen N Qu F Guo J Understanding the Multiple Effects of PCBs on Lipid Metabolism
description	Qiuli Shan,1,2,* Hongmei Li,1,* Ningning Chen,1,* Fan Qu,1 Jing Guo1 1College of Biological Science and Technology, University of Jinan, Jinan 250022, People’s Republic of China; 2State Key Laboratory of Environmental Chemistry and Eco-Toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiuli Shan Email bio_shanql@ujn.edu.cnAbstract: Polychlorinated biphenyls (PCBs) are a typical class of environmental contaminants recently shown to be metabolism-disrupting chemicals. Lipids are a highly complex group of biomolecules that not only form the structural basis of biofilms but also act as signaling molecules and energy sources. Lipid metabolic disorders contribute to multiple diseases, including obesity, diabetes, fatty liver, and metabolic syndromes. Although previous literature has reported that PCBs can affect lipid metabolism, including lipid synthesis, uptake, and elimination, few systematic summaries of the detailed process of lipid metabolism caused by PCB exposure have been published. Lipid metabolic processes involve many molecules; however, the key factors that are sensitive to PCB exposure have not been fully clarified. Here, we summarize the recent developments in PCB research with a focus on biomarkers of lipid metabolic disorders related to environmental exposures.Keywords: PCBs, metabolism-disrupting chemicals, hepatocytes, lipid metabolism
format	article
author	Shan Q Li H Chen N Qu F Guo J
author_facet	Shan Q Li H Chen N Qu F Guo J
author_sort	Shan Q
title	Understanding the Multiple Effects of PCBs on Lipid Metabolism
title_short	Understanding the Multiple Effects of PCBs on Lipid Metabolism
title_full	Understanding the Multiple Effects of PCBs on Lipid Metabolism
title_fullStr	Understanding the Multiple Effects of PCBs on Lipid Metabolism
title_full_unstemmed	Understanding the Multiple Effects of PCBs on Lipid Metabolism
title_sort	understanding the multiple effects of pcbs on lipid metabolism
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/171214658aa74dda9026f3bcd676246c
work_keys_str_mv	AT shanq understandingthemultipleeffectsofpcbsonlipidmetabolism AT lih understandingthemultipleeffectsofpcbsonlipidmetabolism AT chenn understandingthemultipleeffectsofpcbsonlipidmetabolism AT quf understandingthemultipleeffectsofpcbsonlipidmetabolism AT guoj understandingthemultipleeffectsofpcbsonlipidmetabolism
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Understanding the Multiple Effects of PCBs on Lipid Metabolism

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