Comparison of cine and real-time cardiac MRI in rhesus macaques

Abstract Cardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Real-Time (RT) cardiac MRI has been tested in a cohor...

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Autores principales:	Amir Moussavi, Sophie Mißbach, Claudia Serrano Ferrel, Hasti Ghasemipour, Kristin Kötz, Charis Drummer, Rüdiger Behr, Wolfram-Hubertus Zimmermann, Susann Boretius
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17149159db284b80ae2d6aa5055bdcb7
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spelling	oai:doaj.org-article:17149159db284b80ae2d6aa5055bdcb72021-12-02T15:52:47ZComparison of cine and real-time cardiac MRI in rhesus macaques10.1038/s41598-021-90106-92045-2322https://doaj.org/article/17149159db284b80ae2d6aa5055bdcb72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90106-9https://doaj.org/toc/2045-2322Abstract Cardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Real-Time (RT) cardiac MRI has been tested in a cohort of ten adult rhesus macaques using a clinical MR-system. In spite of lower tissue contrast and sharpness of RT-MRI, cardiac functions were similarly well assessed by RT-MRI compared to cine MRI (similar intra-subject repeatability). However, systematic underestimation of the end-diastolic volume (31 ± 9%), end-systolic volume (20 ± 11%), stroke volume (40 ± 12%) and ejection fraction (13 ± 9%) hamper the comparability of RT-MRI results with those of other cardiac MRI methods. Yet, the underestimations were very consistent (< 5% variability) for repetitive measurements, making RT-MRI an appropriate alternative to cine MRI for longitudinal studies. In addition, RT-MRI enabled the analysis of cardio-respiratory coupling. All functional parameters showed lower values during expiration compared to inspiration, most likely due to the pressure-controlled artificial ventilation. In conclusion, despite systematic underestimation of the functional parameters, RT-MRI allowed the assessment of left ventricular function in macaques with significantly less experimental effort, measurement time, risk and burden for the animals compared to cine MRI.Amir MoussaviSophie MißbachClaudia Serrano FerrelHasti GhasemipourKristin KötzCharis DrummerRüdiger BehrWolfram-Hubertus ZimmermannSusann BoretiusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amir Moussavi Sophie Mißbach Claudia Serrano Ferrel Hasti Ghasemipour Kristin Kötz Charis Drummer Rüdiger Behr Wolfram-Hubertus Zimmermann Susann Boretius Comparison of cine and real-time cardiac MRI in rhesus macaques
description	Abstract Cardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Real-Time (RT) cardiac MRI has been tested in a cohort of ten adult rhesus macaques using a clinical MR-system. In spite of lower tissue contrast and sharpness of RT-MRI, cardiac functions were similarly well assessed by RT-MRI compared to cine MRI (similar intra-subject repeatability). However, systematic underestimation of the end-diastolic volume (31 ± 9%), end-systolic volume (20 ± 11%), stroke volume (40 ± 12%) and ejection fraction (13 ± 9%) hamper the comparability of RT-MRI results with those of other cardiac MRI methods. Yet, the underestimations were very consistent (< 5% variability) for repetitive measurements, making RT-MRI an appropriate alternative to cine MRI for longitudinal studies. In addition, RT-MRI enabled the analysis of cardio-respiratory coupling. All functional parameters showed lower values during expiration compared to inspiration, most likely due to the pressure-controlled artificial ventilation. In conclusion, despite systematic underestimation of the functional parameters, RT-MRI allowed the assessment of left ventricular function in macaques with significantly less experimental effort, measurement time, risk and burden for the animals compared to cine MRI.
format	article
author	Amir Moussavi Sophie Mißbach Claudia Serrano Ferrel Hasti Ghasemipour Kristin Kötz Charis Drummer Rüdiger Behr Wolfram-Hubertus Zimmermann Susann Boretius
author_facet	Amir Moussavi Sophie Mißbach Claudia Serrano Ferrel Hasti Ghasemipour Kristin Kötz Charis Drummer Rüdiger Behr Wolfram-Hubertus Zimmermann Susann Boretius
author_sort	Amir Moussavi
title	Comparison of cine and real-time cardiac MRI in rhesus macaques
title_short	Comparison of cine and real-time cardiac MRI in rhesus macaques
title_full	Comparison of cine and real-time cardiac MRI in rhesus macaques
title_fullStr	Comparison of cine and real-time cardiac MRI in rhesus macaques
title_full_unstemmed	Comparison of cine and real-time cardiac MRI in rhesus macaques
title_sort	comparison of cine and real-time cardiac mri in rhesus macaques
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17149159db284b80ae2d6aa5055bdcb7
work_keys_str_mv	AT amirmoussavi comparisonofcineandrealtimecardiacmriinrhesusmacaques AT sophiemißbach comparisonofcineandrealtimecardiacmriinrhesusmacaques AT claudiaserranoferrel comparisonofcineandrealtimecardiacmriinrhesusmacaques AT hastighasemipour comparisonofcineandrealtimecardiacmriinrhesusmacaques AT kristinkotz comparisonofcineandrealtimecardiacmriinrhesusmacaques AT charisdrummer comparisonofcineandrealtimecardiacmriinrhesusmacaques AT rudigerbehr comparisonofcineandrealtimecardiacmriinrhesusmacaques AT wolframhubertuszimmermann comparisonofcineandrealtimecardiacmriinrhesusmacaques AT susannboretius comparisonofcineandrealtimecardiacmriinrhesusmacaques
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Comparison of cine and real-time cardiac MRI in rhesus macaques

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