Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer.

Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer.

In this study, we hypothesized that androgen-deprivation therapy (ADT) in prostate cancer, although initially efficient, induces changes in the tumor kinome, which subsequently promote development of castration-resistant (CR) disease. Recognizing the correlation between tumor hypoxia and poor progno...

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Autores principales: Kathrine Røe, Åse Bratland, Ljiljana Vlatkovic, Harald Bull Ragnum, Marie Grøn Saelen, Dag Rune Olsen, Laure Marignol, Anne Hansen Ree
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/17199364992041ea834ef7596d33118e
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