Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice

Abstract Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance exercise training for 10 weeks. Trained mice presented higher muscle weight...

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Autores principales:	Gabriela Alves Bronczek, Gabriela Moreira Soares, Jaqueline Fernandes de Barros, Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Emílio Marconato-Júnior, Lucas Zangerolamo, Carine Marmentini, Antonio Carlos Boschero, José Maria Costa-Júnior
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/171b23e3289a4af4880b949fc27e88b4
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spelling	oai:doaj.org-article:171b23e3289a4af4880b949fc27e88b42021-12-02T16:45:39ZResistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice10.1038/s41598-021-88105-x2045-2322https://doaj.org/article/171b23e3289a4af4880b949fc27e88b42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88105-xhttps://doaj.org/toc/2045-2322Abstract Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance exercise training for 10 weeks. Trained mice presented higher muscle weight and maximum voluntary carrying capacity, combined with reduced body weight gain and fat deposition. Resistance training improved glucose tolerance and reduced glycemia, with no alterations in insulin sensitivity. In addition, trained mice displayed higher insulinemia in fed state, associated with increased glucose-stimulated insulin secretion. Islets from trained mice showed reduced expression of genes related to endoplasmic reticulum (ER) stress, associated with increased expression of Ins2. INS-1E beta-cells incubated with serum from trained mice displayed similar pattern of insulin secretion and gene expression than isolated islets from trained mice. When exposed to CPA (an ER stress inducer), the serum from trained mice partially preserved the secretory function of INS-1E cells, and prevented CPA-induced apoptosis. These data suggest that resistance training, in healthy mice, improves glucose homeostasis by enhancing insulin secretion, which could be driven, at least in part, by humoral factors.Gabriela Alves BronczekGabriela Moreira SoaresJaqueline Fernandes de BarrosJean Franciesco VettorazziMirian Ayumi KurautiEmílio Marconato-JúniorLucas ZangerolamoCarine MarmentiniAntonio Carlos BoscheroJosé Maria Costa-JúniorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabriela Alves Bronczek Gabriela Moreira Soares Jaqueline Fernandes de Barros Jean Franciesco Vettorazzi Mirian Ayumi Kurauti Emílio Marconato-Júnior Lucas Zangerolamo Carine Marmentini Antonio Carlos Boschero José Maria Costa-Júnior Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
description	Abstract Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance exercise training for 10 weeks. Trained mice presented higher muscle weight and maximum voluntary carrying capacity, combined with reduced body weight gain and fat deposition. Resistance training improved glucose tolerance and reduced glycemia, with no alterations in insulin sensitivity. In addition, trained mice displayed higher insulinemia in fed state, associated with increased glucose-stimulated insulin secretion. Islets from trained mice showed reduced expression of genes related to endoplasmic reticulum (ER) stress, associated with increased expression of Ins2. INS-1E beta-cells incubated with serum from trained mice displayed similar pattern of insulin secretion and gene expression than isolated islets from trained mice. When exposed to CPA (an ER stress inducer), the serum from trained mice partially preserved the secretory function of INS-1E cells, and prevented CPA-induced apoptosis. These data suggest that resistance training, in healthy mice, improves glucose homeostasis by enhancing insulin secretion, which could be driven, at least in part, by humoral factors.
format	article
author	Gabriela Alves Bronczek Gabriela Moreira Soares Jaqueline Fernandes de Barros Jean Franciesco Vettorazzi Mirian Ayumi Kurauti Emílio Marconato-Júnior Lucas Zangerolamo Carine Marmentini Antonio Carlos Boschero José Maria Costa-Júnior
author_facet	Gabriela Alves Bronczek Gabriela Moreira Soares Jaqueline Fernandes de Barros Jean Franciesco Vettorazzi Mirian Ayumi Kurauti Emílio Marconato-Júnior Lucas Zangerolamo Carine Marmentini Antonio Carlos Boschero José Maria Costa-Júnior
author_sort	Gabriela Alves Bronczek
title	Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
title_short	Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
title_full	Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
title_fullStr	Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
title_full_unstemmed	Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
title_sort	resistance exercise training improves glucose homeostasis by enhancing insulin secretion in c57bl/6 mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/171b23e3289a4af4880b949fc27e88b4
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Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice

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