Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib, and report heterogeneous erlotinib delivery to in...

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Autores principales: Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, Minjee Kim, Alison Roos, David Calligaris, Michael S. Regan, Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Aaron J. Johnson, Fa-Ke Lu, X. Sunney Xie, Brian A. Joughin, Raven J. Reddy, Sen Peng, Walid M. Abdelmoula, Pamela R. Jackson, Aarti Kolluri, Katherine A. Kellersberger, Jeffrey N. Agar, Douglas A. Lauffenburger, Kristin R. Swanson, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y. R. Agar
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/17219987055045cbbd74e20d4356a523
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spelling oai:doaj.org-article:17219987055045cbbd74e20d4356a5232021-12-02T14:39:05ZIntegrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma10.1038/s41467-018-07334-32041-1723https://doaj.org/article/17219987055045cbbd74e20d4356a5232018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07334-3https://doaj.org/toc/2041-1723Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib, and report heterogeneous erlotinib delivery to intracranial tumors to be inadequate to inhibit EGFR signaling.Elizabeth C. RandallKristina B. EmdalJanice K. LaramyMinjee KimAlison RoosDavid CalligarisMichael S. ReganShiv K. GuptaAnn C. MladekBrett L. CarlsonAaron J. JohnsonFa-Ke LuX. Sunney XieBrian A. JoughinRaven J. ReddySen PengWalid M. AbdelmoulaPamela R. JacksonAarti KolluriKatherine A. KellersbergerJeffrey N. AgarDouglas A. LauffenburgerKristin R. SwansonNhan L. TranWilliam F. ElmquistForest M. WhiteJann N. SarkariaNathalie Y. R. AgarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elizabeth C. Randall
Kristina B. Emdal
Janice K. Laramy
Minjee Kim
Alison Roos
David Calligaris
Michael S. Regan
Shiv K. Gupta
Ann C. Mladek
Brett L. Carlson
Aaron J. Johnson
Fa-Ke Lu
X. Sunney Xie
Brian A. Joughin
Raven J. Reddy
Sen Peng
Walid M. Abdelmoula
Pamela R. Jackson
Aarti Kolluri
Katherine A. Kellersberger
Jeffrey N. Agar
Douglas A. Lauffenburger
Kristin R. Swanson
Nhan L. Tran
William F. Elmquist
Forest M. White
Jann N. Sarkaria
Nathalie Y. R. Agar
Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
description Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib, and report heterogeneous erlotinib delivery to intracranial tumors to be inadequate to inhibit EGFR signaling.
format article
author Elizabeth C. Randall
Kristina B. Emdal
Janice K. Laramy
Minjee Kim
Alison Roos
David Calligaris
Michael S. Regan
Shiv K. Gupta
Ann C. Mladek
Brett L. Carlson
Aaron J. Johnson
Fa-Ke Lu
X. Sunney Xie
Brian A. Joughin
Raven J. Reddy
Sen Peng
Walid M. Abdelmoula
Pamela R. Jackson
Aarti Kolluri
Katherine A. Kellersberger
Jeffrey N. Agar
Douglas A. Lauffenburger
Kristin R. Swanson
Nhan L. Tran
William F. Elmquist
Forest M. White
Jann N. Sarkaria
Nathalie Y. R. Agar
author_facet Elizabeth C. Randall
Kristina B. Emdal
Janice K. Laramy
Minjee Kim
Alison Roos
David Calligaris
Michael S. Regan
Shiv K. Gupta
Ann C. Mladek
Brett L. Carlson
Aaron J. Johnson
Fa-Ke Lu
X. Sunney Xie
Brian A. Joughin
Raven J. Reddy
Sen Peng
Walid M. Abdelmoula
Pamela R. Jackson
Aarti Kolluri
Katherine A. Kellersberger
Jeffrey N. Agar
Douglas A. Lauffenburger
Kristin R. Swanson
Nhan L. Tran
William F. Elmquist
Forest M. White
Jann N. Sarkaria
Nathalie Y. R. Agar
author_sort Elizabeth C. Randall
title Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
title_short Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
title_full Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
title_fullStr Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
title_full_unstemmed Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
title_sort integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/17219987055045cbbd74e20d4356a523
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