Revision of the concept of anti-angiogenesis and its applications in tumor treatment

Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventi...

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Autores principales:	Wen-Hui Yang, Jun Xu, Jian-Bing Mu, Jun Xie
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/17226f6351f3463cb5a27d872c318c54
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spelling	oai:doaj.org-article:17226f6351f3463cb5a27d872c318c542021-12-02T14:08:43ZRevision of the concept of anti-angiogenesis and its applications in tumor treatment2095-882X10.1016/j.cdtm.2017.01.002https://doaj.org/article/17226f6351f3463cb5a27d872c318c542017-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300998https://doaj.org/toc/2095-882XAnti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer. Keywords: Anti-angiogenesis, Angiogenesis, Vascular endothelial growth factor, CancerWen-Hui YangJun XuJian-Bing MuJun XieKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 1, Pp 33-40 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wen-Hui Yang Jun Xu Jian-Bing Mu Jun Xie Revision of the concept of anti-angiogenesis and its applications in tumor treatment
description	Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer. Keywords: Anti-angiogenesis, Angiogenesis, Vascular endothelial growth factor, Cancer
format	article
author	Wen-Hui Yang Jun Xu Jian-Bing Mu Jun Xie
author_facet	Wen-Hui Yang Jun Xu Jian-Bing Mu Jun Xie
author_sort	Wen-Hui Yang
title	Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_short	Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_full	Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_fullStr	Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_full_unstemmed	Revision of the concept of anti-angiogenesis and its applications in tumor treatment
title_sort	revision of the concept of anti-angiogenesis and its applications in tumor treatment
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/17226f6351f3463cb5a27d872c318c54
work_keys_str_mv	AT wenhuiyang revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment AT junxu revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment AT jianbingmu revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment AT junxie revisionoftheconceptofantiangiogenesisanditsapplicationsintumortreatment
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Revision of the concept of anti-angiogenesis and its applications in tumor treatment

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