R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours extremely sensitive to Wnt ligand inhibition.

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Autores principales:	Teng Han, Emma M. Schatoff, Charles Murphy, Maria Paz Zafra, John E. Wilkinson, Olivier Elemento, Lukas E. Dow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1723273cb2e14f359f103ef93504189d
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spelling	oai:doaj.org-article:1723273cb2e14f359f103ef93504189d2021-12-02T14:40:59ZR-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine10.1038/ncomms159452041-1723https://doaj.org/article/1723273cb2e14f359f103ef93504189d2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15945https://doaj.org/toc/2041-1723Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours extremely sensitive to Wnt ligand inhibition.Teng HanEmma M. SchatoffCharles MurphyMaria Paz ZafraJohn E. WilkinsonOlivier ElementoLukas E. DowNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teng Han Emma M. Schatoff Charles Murphy Maria Paz Zafra John E. Wilkinson Olivier Elemento Lukas E. Dow R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
description	Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours extremely sensitive to Wnt ligand inhibition.
format	article
author	Teng Han Emma M. Schatoff Charles Murphy Maria Paz Zafra John E. Wilkinson Olivier Elemento Lukas E. Dow
author_facet	Teng Han Emma M. Schatoff Charles Murphy Maria Paz Zafra John E. Wilkinson Olivier Elemento Lukas E. Dow
author_sort	Teng Han
title	R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
title_short	R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
title_full	R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
title_fullStr	R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
title_full_unstemmed	R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
title_sort	r-spondin chromosome rearrangements drive wnt-dependent tumour initiation and maintenance in the intestine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1723273cb2e14f359f103ef93504189d
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R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

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