R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours extremely sensitive to Wnt ligand inhibition.

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Autores principales: Teng Han, Emma M. Schatoff, Charles Murphy, Maria Paz Zafra, John E. Wilkinson, Olivier Elemento, Lukas E. Dow
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/1723273cb2e14f359f103ef93504189d
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