R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours extremely sensitive to Wnt ligand inhibition.
Enregistré dans:
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/1723273cb2e14f359f103ef93504189d |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|