Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

BackgroundChronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota p...

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Autores principales:	Runqiu Liu, Cong Peng, Danrong Jing, Yangjian Xiao, Wu Zhu, Shuang Zhao, Jianglin Zhang, Xiang Chen, Jie Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronic spontaneous urticaria symptomatic dermographism gut microbiota Subdoligranulum Ruminococcus bromii Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1728e8a417fe43e38022bb32a8a03ce1
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spelling	oai:doaj.org-article:1728e8a417fe43e38022bb32a8a03ce12021-11-09T05:40:25ZBiomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism2235-298810.3389/fcimb.2021.703126https://doaj.org/article/1728e8a417fe43e38022bb32a8a03ce12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.703126/fullhttps://doaj.org/toc/2235-2988BackgroundChronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.MethodsA case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.ResultsThe alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. Subdoligranulum and Ruminococcus bromii decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. Enterobacteriaceae and Klebsiella were found to be positively correlated with the duration of CSD, while Clostridium disporicum was positively correlated with the dermatology life quality index (DLQI).ConclusionsThe gut microbiota of CSD patients is imbalanced. Subdoligranulum and Ruminococcus bromii are the gut microbiota biomarkers in CSD.Runqiu LiuRunqiu LiuRunqiu LiuRunqiu LiuCong PengCong PengCong PengCong PengCong PengDanrong JingDanrong JingDanrong JingDanrong JingDanrong JingYangjian XiaoYangjian XiaoYangjian XiaoYangjian XiaoWu ZhuWu ZhuWu ZhuWu ZhuWu ZhuShuang ZhaoShuang ZhaoShuang ZhaoShuang ZhaoJianglin ZhangJianglin ZhangJianglin ZhangJianglin ZhangXiang ChenXiang ChenXiang ChenXiang ChenXiang ChenJie LiJie LiJie LiJie LiJie LiFrontiers Media S.A.articlechronic spontaneous urticariasymptomatic dermographismgut microbiotaSubdoligranulumRuminococcus bromiiMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic spontaneous urticaria symptomatic dermographism gut microbiota Subdoligranulum Ruminococcus bromii Microbiology QR1-502
spellingShingle	chronic spontaneous urticaria symptomatic dermographism gut microbiota Subdoligranulum Ruminococcus bromii Microbiology QR1-502 Runqiu Liu Runqiu Liu Runqiu Liu Runqiu Liu Cong Peng Cong Peng Cong Peng Cong Peng Cong Peng Danrong Jing Danrong Jing Danrong Jing Danrong Jing Danrong Jing Yangjian Xiao Yangjian Xiao Yangjian Xiao Yangjian Xiao Wu Zhu Wu Zhu Wu Zhu Wu Zhu Wu Zhu Shuang Zhao Shuang Zhao Shuang Zhao Shuang Zhao Jianglin Zhang Jianglin Zhang Jianglin Zhang Jianglin Zhang Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Jie Li Jie Li Jie Li Jie Li Jie Li Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
description	BackgroundChronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.MethodsA case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.ResultsThe alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. Subdoligranulum and Ruminococcus bromii decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. Enterobacteriaceae and Klebsiella were found to be positively correlated with the duration of CSD, while Clostridium disporicum was positively correlated with the dermatology life quality index (DLQI).ConclusionsThe gut microbiota of CSD patients is imbalanced. Subdoligranulum and Ruminococcus bromii are the gut microbiota biomarkers in CSD.
format	article
author	Runqiu Liu Runqiu Liu Runqiu Liu Runqiu Liu Cong Peng Cong Peng Cong Peng Cong Peng Cong Peng Danrong Jing Danrong Jing Danrong Jing Danrong Jing Danrong Jing Yangjian Xiao Yangjian Xiao Yangjian Xiao Yangjian Xiao Wu Zhu Wu Zhu Wu Zhu Wu Zhu Wu Zhu Shuang Zhao Shuang Zhao Shuang Zhao Shuang Zhao Jianglin Zhang Jianglin Zhang Jianglin Zhang Jianglin Zhang Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Jie Li Jie Li Jie Li Jie Li Jie Li
author_facet	Runqiu Liu Runqiu Liu Runqiu Liu Runqiu Liu Cong Peng Cong Peng Cong Peng Cong Peng Cong Peng Danrong Jing Danrong Jing Danrong Jing Danrong Jing Danrong Jing Yangjian Xiao Yangjian Xiao Yangjian Xiao Yangjian Xiao Wu Zhu Wu Zhu Wu Zhu Wu Zhu Wu Zhu Shuang Zhao Shuang Zhao Shuang Zhao Shuang Zhao Jianglin Zhang Jianglin Zhang Jianglin Zhang Jianglin Zhang Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Jie Li Jie Li Jie Li Jie Li Jie Li
author_sort	Runqiu Liu
title	Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
title_short	Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
title_full	Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
title_fullStr	Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
title_full_unstemmed	Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism
title_sort	biomarkers of gut microbiota in chronic spontaneous urticaria and symptomatic dermographism
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1728e8a417fe43e38022bb32a8a03ce1
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Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

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