Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging

Abstract The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), a...

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Autores principales:	Clement Papadacci, Victor Finel, Jean Provost, Olivier Villemain, Patrick Bruneval, Jean-Luc Gennisson, Mickael Tanter, Mathias Fink, Mathieu Pernot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/172b85dc238144069fe0e23b27c936ff
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spelling	oai:doaj.org-article:172b85dc238144069fe0e23b27c936ff2021-12-02T16:07:01ZImaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging10.1038/s41598-017-00946-72045-2322https://doaj.org/article/172b85dc238144069fe0e23b27c936ff2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00946-7https://doaj.org/toc/2045-2322Abstract The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients.Clement PapadacciVictor FinelJean ProvostOlivier VillemainPatrick BrunevalJean-Luc GennissonMickael TanterMathias FinkMathieu PernotNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clement Papadacci Victor Finel Jean Provost Olivier Villemain Patrick Bruneval Jean-Luc Gennisson Mickael Tanter Mathias Fink Mathieu Pernot Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
description	Abstract The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients.
format	article
author	Clement Papadacci Victor Finel Jean Provost Olivier Villemain Patrick Bruneval Jean-Luc Gennisson Mickael Tanter Mathias Fink Mathieu Pernot
author_facet	Clement Papadacci Victor Finel Jean Provost Olivier Villemain Patrick Bruneval Jean-Luc Gennisson Mickael Tanter Mathias Fink Mathieu Pernot
author_sort	Clement Papadacci
title	Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_short	Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_full	Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_fullStr	Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_full_unstemmed	Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_sort	imaging the dynamics of cardiac fiber orientation in vivo using 3d ultrasound backscatter tensor imaging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/172b85dc238144069fe0e23b27c936ff
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Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging

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