Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies

The present systematic review and meta-analysis was conducted to assess the effect of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA). We systematically searched all potential articles in the main databases, including PubMed, Scopus, EMBASE, Web of Sciences (ISI), and Cochrane Center. T...

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Autores principales:	Amal Saki, Elham Rajaei, Fakher Rahim
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2021
Materias:	adverse events efficacy safety meta-analysis rheumatoid arthritis tocilizumab. Medicine R
Acceso en línea:	https://doaj.org/article/1732af7b3ed2409c9ee8972c9cb252ea
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spelling	oai:doaj.org-article:1732af7b3ed2409c9ee8972c9cb252ea2021-12-02T19:19:13ZSafety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies0034-62332084-983410.5114/reum.2021.107026https://doaj.org/article/1732af7b3ed2409c9ee8972c9cb252ea2021-07-01T00:00:00Zhttps://www.termedia.pl/Safety-and-efficacy-of-tocilizumab-for-rheumatoid-arthritis-a-systematic-review-and-metaanalysis-of-clinical-trial-studies,18,44425,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834The present systematic review and meta-analysis was conducted to assess the effect of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA). We systematically searched all potential articles in the main databases, including PubMed, Scopus, EMBASE, Web of Sciences (ISI), and Cochrane Center. The search was subsequently updated in December 2020. The initial review and extraction of information were performed independently by two authors to collect the first author and publication year; sample size; mean age of the intervention and control groups; the dose of TCZ, and the follow-up duration. Outcomes of interest include the ACR20, ACR50, ACR70, total complication rate, and the occurrence of remission. Any disagreements between the reviewers were resolved by discussion and re-check of the article and consultation with a third reviewer. After reviewing and culling, 15 clinical trials comparing the clinical efficacy of TCZ and its comparators in the treatment of patients with RA entered the qualitative and quantitative synthesis. Tocilizumab 8 mg was statistically better than 4 mg or placebo for ACR responses. Significant clinical adverse events in patients with RA treated with TCZ, such as abnormal liver function tests (LFTs) and infections, were more frequent than in comparator groups. This systematic review and meta-analysis suggest that the combination therapy of TCZ with other drugs such as methotrexate and disease-modifying antirheumatic drugs has been studied for various clinical effects concerning safety and clinically significant adverse events. Although the data are promising, long-term performance and safety data need to be fully identified, as well as the risks and benefits of TCZ, especially appropriate timing, dosage, and regimen.Amal SakiElham RajaeiFakher RahimTermedia Publishing Housearticleadverse events efficacy safety meta-analysis rheumatoid arthritis adverse events tocilizumab.MedicineRENRheumatology, Vol 59, Iss 3, Pp 169-179 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse events efficacy safety meta-analysis rheumatoid arthritis adverse events tocilizumab. Medicine R
spellingShingle	adverse events efficacy safety meta-analysis rheumatoid arthritis adverse events tocilizumab. Medicine R Amal Saki Elham Rajaei Fakher Rahim Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
description	The present systematic review and meta-analysis was conducted to assess the effect of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA). We systematically searched all potential articles in the main databases, including PubMed, Scopus, EMBASE, Web of Sciences (ISI), and Cochrane Center. The search was subsequently updated in December 2020. The initial review and extraction of information were performed independently by two authors to collect the first author and publication year; sample size; mean age of the intervention and control groups; the dose of TCZ, and the follow-up duration. Outcomes of interest include the ACR20, ACR50, ACR70, total complication rate, and the occurrence of remission. Any disagreements between the reviewers were resolved by discussion and re-check of the article and consultation with a third reviewer. After reviewing and culling, 15 clinical trials comparing the clinical efficacy of TCZ and its comparators in the treatment of patients with RA entered the qualitative and quantitative synthesis. Tocilizumab 8 mg was statistically better than 4 mg or placebo for ACR responses. Significant clinical adverse events in patients with RA treated with TCZ, such as abnormal liver function tests (LFTs) and infections, were more frequent than in comparator groups. This systematic review and meta-analysis suggest that the combination therapy of TCZ with other drugs such as methotrexate and disease-modifying antirheumatic drugs has been studied for various clinical effects concerning safety and clinically significant adverse events. Although the data are promising, long-term performance and safety data need to be fully identified, as well as the risks and benefits of TCZ, especially appropriate timing, dosage, and regimen.
format	article
author	Amal Saki Elham Rajaei Fakher Rahim
author_facet	Amal Saki Elham Rajaei Fakher Rahim
author_sort	Amal Saki
title	Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
title_short	Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
title_full	Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
title_fullStr	Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
title_full_unstemmed	Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
title_sort	safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies
publisher	Termedia Publishing House
publishDate	2021
url	https://doaj.org/article/1732af7b3ed2409c9ee8972c9cb252ea
work_keys_str_mv	AT amalsaki safetyandefficacyoftocilizumabforrheumatoidarthritisasystematicreviewandmetaanalysisofclinicaltrialstudies AT elhamrajaei safetyandefficacyoftocilizumabforrheumatoidarthritisasystematicreviewandmetaanalysisofclinicaltrialstudies AT fakherrahim safetyandefficacyoftocilizumabforrheumatoidarthritisasystematicreviewandmetaanalysisofclinicaltrialstudies
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Safety and efficacy of tocilizumab for rheumatoid arthritis: a systematic review and metaanalysis of clinical trial studies

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