Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures

Three-dimensional (3D) printing is an emerging technology that has high application potential for individualized medicines and complex solid dosage forms. This study is designed to explore binder jet 3D printing (BJ-3DP) for the development of high-precision and repeatable compound levetiracetam-pyr...

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Autores principales:	Xiaoxuan Hong, Xiaolu Han, Xianfu Li, Jiale Li, Zengming Wang, Aiping Zheng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	binder jet 3D printing compound dispersible tablets multicompartmental structure coffee ring personalized administration Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1734a19227e8498e9375b8c412533cd4
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spelling	oai:doaj.org-article:1734a19227e8498e9375b8c412533cd42021-11-25T18:40:37ZBinder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures10.3390/pharmaceutics131117801999-4923https://doaj.org/article/1734a19227e8498e9375b8c412533cd42021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1780https://doaj.org/toc/1999-4923Three-dimensional (3D) printing is an emerging technology that has high application potential for individualized medicines and complex solid dosage forms. This study is designed to explore binder jet 3D printing (BJ-3DP) for the development of high-precision and repeatable compound levetiracetam-pyridoxine hydrochloride (LEV-PN) multicompartmental structure dispersible tablets. PN was dissolved in printing ink directly and accurately jetted into the middle, nested layer of the tablet, and precise control of the drug dose was achieved through the design of printing layers. With modification of the drying method, the “coffee ring” effect caused by drug migration during the curing and molding of the tablets was overcome. Furthermore, 3D topography showed that the tablets have a promising surface morphology. Scanning electron microscopy and porosity results indicated that the tablets have a loose interior and tight exterior, which would ensure good mechanical properties while enabling the tablet to disintegrate quickly in the mouth and achieve rapid release of the two drugs. This study used BJ-3DP technology to prepare personalized multicompartmental structures of drug systems and provides a basis for the development of complex preparations.Xiaoxuan HongXiaolu HanXianfu LiJiale LiZengming WangAiping ZhengMDPI AGarticlebinder jet 3D printingcompound dispersible tabletsmulticompartmental structurecoffee ringpersonalized administrationPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1780, p 1780 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	binder jet 3D printing compound dispersible tablets multicompartmental structure coffee ring personalized administration Pharmacy and materia medica RS1-441
spellingShingle	binder jet 3D printing compound dispersible tablets multicompartmental structure coffee ring personalized administration Pharmacy and materia medica RS1-441 Xiaoxuan Hong Xiaolu Han Xianfu Li Jiale Li Zengming Wang Aiping Zheng Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures
description	Three-dimensional (3D) printing is an emerging technology that has high application potential for individualized medicines and complex solid dosage forms. This study is designed to explore binder jet 3D printing (BJ-3DP) for the development of high-precision and repeatable compound levetiracetam-pyridoxine hydrochloride (LEV-PN) multicompartmental structure dispersible tablets. PN was dissolved in printing ink directly and accurately jetted into the middle, nested layer of the tablet, and precise control of the drug dose was achieved through the design of printing layers. With modification of the drying method, the “coffee ring” effect caused by drug migration during the curing and molding of the tablets was overcome. Furthermore, 3D topography showed that the tablets have a promising surface morphology. Scanning electron microscopy and porosity results indicated that the tablets have a loose interior and tight exterior, which would ensure good mechanical properties while enabling the tablet to disintegrate quickly in the mouth and achieve rapid release of the two drugs. This study used BJ-3DP technology to prepare personalized multicompartmental structures of drug systems and provides a basis for the development of complex preparations.
format	article
author	Xiaoxuan Hong Xiaolu Han Xianfu Li Jiale Li Zengming Wang Aiping Zheng
author_facet	Xiaoxuan Hong Xiaolu Han Xianfu Li Jiale Li Zengming Wang Aiping Zheng
author_sort	Xiaoxuan Hong
title	Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures
title_short	Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures
title_full	Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures
title_fullStr	Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures
title_full_unstemmed	Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures
title_sort	binder jet 3d printing of compound lev-pn dispersible tablets: an innovative approach for fabricating drug systems with multicompartmental structures
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1734a19227e8498e9375b8c412533cd4
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_version_	1718410817921089536

Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures

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