Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Jun-Ying Wang,1 Jie Chen,1 Jiang Yang,2 Hao Wang,1 Xiu Shen,1 Yuan-Ming Sun,1 Meili Guo,3 Xiao-Dong Zhang4 1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 2E...

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Autores principales:	Wang JY, Chen J, Yang J, Wang H, Shen X, Sun YM, Guo M, Zhang XD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Gold clusters in vivo toxicity long-term cancer therpy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1734de542aa34e4aab5daa6e1025b910
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spelling	oai:doaj.org-article:1734de542aa34e4aab5daa6e1025b9102021-12-02T02:38:19ZEffects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy1178-2013https://doaj.org/article/1734de542aa34e4aab5daa6e1025b9102016-07-01T00:00:00Zhttps://www.dovepress.com/effects-of-surface-charges-of-gold-nanoclusters--on-long-term-in-vivo--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jun-Ying Wang,1 Jie Chen,1 Jiang Yang,2 Hao Wang,1 Xiu Shen,1 Yuan-Ming Sun,1 Meili Guo,3 Xiao-Dong Zhang4 1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 2Environment, Energy and Natural Resources Center, Department of Environmental Science and Engineering, Fudan University, Shanghai, 3Department of Physics, School of Science, Tianjin Chengjian University, 4Department of Physics, School of Science, Tianjin University, Tianjin, People’s Republic of China Abstract: Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system. Keywords: gold clusters, in vivo toxicity, long-term, cancer therapyWang JYChen JYang JWang HShen XSun YMGuo MZhang XDDove Medical PressarticleGold clustersin vivo toxicitylong-termcancer therpyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3475-3485 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold clusters in vivo toxicity long-term cancer therpy Medicine (General) R5-920
spellingShingle	Gold clusters in vivo toxicity long-term cancer therpy Medicine (General) R5-920 Wang JY Chen J Yang J Wang H Shen X Sun YM Guo M Zhang XD Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
description	Jun-Ying Wang,1 Jie Chen,1 Jiang Yang,2 Hao Wang,1 Xiu Shen,1 Yuan-Ming Sun,1 Meili Guo,3 Xiao-Dong Zhang4 1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 2Environment, Energy and Natural Resources Center, Department of Environmental Science and Engineering, Fudan University, Shanghai, 3Department of Physics, School of Science, Tianjin Chengjian University, 4Department of Physics, School of Science, Tianjin University, Tianjin, People’s Republic of China Abstract: Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system. Keywords: gold clusters, in vivo toxicity, long-term, cancer therapy
format	article
author	Wang JY Chen J Yang J Wang H Shen X Sun YM Guo M Zhang XD
author_facet	Wang JY Chen J Yang J Wang H Shen X Sun YM Guo M Zhang XD
author_sort	Wang JY
title	Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_short	Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_full	Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_fullStr	Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_full_unstemmed	Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
title_sort	effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1734de542aa34e4aab5daa6e1025b910
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Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

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