Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reac...

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Autores principales:	Ting Chen, Weiwei Zeng, Changjun Tie, Mian Yu, Huisong Hao, Yang Deng, Qianqian Li, Hairong Zheng, Meiying Wu, Lin Mei
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95
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spelling	oai:doaj.org-article:1736e1b770c14cbe97f461bab5836d952021-11-30T04:16:47ZEngineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics2452-199X10.1016/j.bioactmat.2021.09.016https://doaj.org/article/1736e1b770c14cbe97f461bab5836d952022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004345https://doaj.org/toc/2452-199XThe imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BP@MS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.Ting ChenWeiwei ZengChangjun TieMian YuHuisong HaoYang DengQianqian LiHairong ZhengMeiying WuLin MeiKeAi Communications Co., Ltd.articleBlack phosphorusOxidative stressTumor microenvironmentSonodynamic therapyTheranosticMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 515-525 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Ting Chen Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
description	The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO2 on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BP@MS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO2-mediated O2 generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.
format	article
author	Ting Chen Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei
author_facet	Ting Chen Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei
author_sort	Ting Chen
title	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
title_short	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
title_full	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
title_fullStr	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
title_full_unstemmed	Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
title_sort	engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/1736e1b770c14cbe97f461bab5836d95
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Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

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