Changes in proinflammatory cytokines and white matter in chronically stressed rats

Ping Yang,1 Zhenyong Gao,1 Handi Zhang,1 Zeman Fang,1 Cairu Wu,1 Haiyun Xu,1,2 Qing-Jun Huang1 1Mental Health Center, 2Department of Anatomy, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China Abstract: Although the pathogenesis of depression, an incapaci...

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Autores principales:	Yang P, Gao Z, Zhang H, Fang Z, Wu C, Xu H, Huang QJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1737e8eb2bec42949d3377589be4dcca
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spelling	oai:doaj.org-article:1737e8eb2bec42949d3377589be4dcca2021-12-02T08:20:03ZChanges in proinflammatory cytokines and white matter in chronically stressed rats1178-2021https://doaj.org/article/1737e8eb2bec42949d3377589be4dcca2015-03-01T00:00:00Zhttp://www.dovepress.com/changes-in-proinflammatory-cytokines-and-white-matter-in-chronically-s-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ping Yang,1 Zhenyong Gao,1 Handi Zhang,1 Zeman Fang,1 Cairu Wu,1 Haiyun Xu,1,2 Qing-Jun Huang1 1Mental Health Center, 2Department of Anatomy, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China Abstract: Although the pathogenesis of depression, an incapacitating psychiatric ailment, remains largely unknown, previous human and animal studies have suggested that both proinflammatory cytokines and altered oligodendrocytes play important roles in the condition. This study examined these two factors in the brains of rats following unpredictable chronic mild stress for 4 weeks, with the hypothesis that chronic stress may affect oligodendrocytes and elevate proinflammatory cytokines in the brain. After suffering unpredictable stressors for 4 weeks, the rats showed depression-like behaviors, including decreased locomotion in the open field, increased immobility time in the forced swim test, and decreased sucrose consumption and less sucrose preference when compared with controls. Immunohistochemical staining of brain sections showed higher immunoreactivity of proinflammatory cytokines in certain brain regions of stressed rats compared with controls; lower immunoreactivity of myelin basic protein and fewer mature oligodendrocytes were seen in the prefrontal cortex, but no demyelination was detected. These results are interpreted and discussed in the context of recent findings from human and animal studies. Keywords: cytokines, depression, myelination, oligodendrocytes, stress Yang PGao ZZhang HFang ZWu CXu HHuang QJDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 597-607 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yang P Gao Z Zhang H Fang Z Wu C Xu H Huang QJ Changes in proinflammatory cytokines and white matter in chronically stressed rats
description	Ping Yang,1 Zhenyong Gao,1 Handi Zhang,1 Zeman Fang,1 Cairu Wu,1 Haiyun Xu,1,2 Qing-Jun Huang1 1Mental Health Center, 2Department of Anatomy, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China Abstract: Although the pathogenesis of depression, an incapacitating psychiatric ailment, remains largely unknown, previous human and animal studies have suggested that both proinflammatory cytokines and altered oligodendrocytes play important roles in the condition. This study examined these two factors in the brains of rats following unpredictable chronic mild stress for 4 weeks, with the hypothesis that chronic stress may affect oligodendrocytes and elevate proinflammatory cytokines in the brain. After suffering unpredictable stressors for 4 weeks, the rats showed depression-like behaviors, including decreased locomotion in the open field, increased immobility time in the forced swim test, and decreased sucrose consumption and less sucrose preference when compared with controls. Immunohistochemical staining of brain sections showed higher immunoreactivity of proinflammatory cytokines in certain brain regions of stressed rats compared with controls; lower immunoreactivity of myelin basic protein and fewer mature oligodendrocytes were seen in the prefrontal cortex, but no demyelination was detected. These results are interpreted and discussed in the context of recent findings from human and animal studies. Keywords: cytokines, depression, myelination, oligodendrocytes, stress
format	article
author	Yang P Gao Z Zhang H Fang Z Wu C Xu H Huang QJ
author_facet	Yang P Gao Z Zhang H Fang Z Wu C Xu H Huang QJ
author_sort	Yang P
title	Changes in proinflammatory cytokines and white matter in chronically stressed rats
title_short	Changes in proinflammatory cytokines and white matter in chronically stressed rats
title_full	Changes in proinflammatory cytokines and white matter in chronically stressed rats
title_fullStr	Changes in proinflammatory cytokines and white matter in chronically stressed rats
title_full_unstemmed	Changes in proinflammatory cytokines and white matter in chronically stressed rats
title_sort	changes in proinflammatory cytokines and white matter in chronically stressed rats
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/1737e8eb2bec42949d3377589be4dcca
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_version_	1718398530066841600

Changes in proinflammatory cytokines and white matter in chronically stressed rats

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