SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.

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Autores principales: Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/173953915c6a47688637a8c938baf515
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spelling oai:doaj.org-article:173953915c6a47688637a8c938baf5152021-12-02T15:35:39ZSKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection10.1038/s41467-019-13659-42041-1723https://doaj.org/article/173953915c6a47688637a8c938baf5152019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13659-4https://doaj.org/toc/2041-1723Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.Nils C. GassenDaniela NiemeyerDoreen MuthVictor M. CormanSilvia MartinelliAlwine GassenKathrin HafnerJan PapiesKirstin MösbauerAndreas ZellnerAnthony S. ZannasAlexander HerrmannFlorian HolsboerRuth Brack-WernerMichael BoshartBertram Müller-MyhsokChristian DrostenMarcel A. MüllerTheo ReinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nils C. Gassen
Daniela Niemeyer
Doreen Muth
Victor M. Corman
Silvia Martinelli
Alwine Gassen
Kathrin Hafner
Jan Papies
Kirstin Mösbauer
Andreas Zellner
Anthony S. Zannas
Alexander Herrmann
Florian Holsboer
Ruth Brack-Werner
Michael Boshart
Bertram Müller-Myhsok
Christian Drosten
Marcel A. Müller
Theo Rein
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
description Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.
format article
author Nils C. Gassen
Daniela Niemeyer
Doreen Muth
Victor M. Corman
Silvia Martinelli
Alwine Gassen
Kathrin Hafner
Jan Papies
Kirstin Mösbauer
Andreas Zellner
Anthony S. Zannas
Alexander Herrmann
Florian Holsboer
Ruth Brack-Werner
Michael Boshart
Bertram Müller-Myhsok
Christian Drosten
Marcel A. Müller
Theo Rein
author_facet Nils C. Gassen
Daniela Niemeyer
Doreen Muth
Victor M. Corman
Silvia Martinelli
Alwine Gassen
Kathrin Hafner
Jan Papies
Kirstin Mösbauer
Andreas Zellner
Anthony S. Zannas
Alexander Herrmann
Florian Holsboer
Ruth Brack-Werner
Michael Boshart
Bertram Müller-Myhsok
Christian Drosten
Marcel A. Müller
Theo Rein
author_sort Nils C. Gassen
title SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
title_short SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
title_full SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
title_fullStr SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
title_full_unstemmed SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
title_sort skp2 attenuates autophagy through beclin1-ubiquitination and its inhibition reduces mers-coronavirus infection
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/173953915c6a47688637a8c938baf515
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