Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.

Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.

<h4>Background</h4>In patients with temporal lobe epilepsy and associated hippocampal sclerosis (TLEhs) there are brain abnormalities extending beyond the presumed epileptogenic zone as revealed separately in conventional magnetic resonance imaging (MRI) and MR diffusion tensor imaging (...

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Autores principales: Simon S Keller, Jan-Christoph Schoene-Bake, Jan S Gerdes, Bernd Weber, Michael Deppe
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/173b4cf1e5204bc1830a070b297e12c7
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spelling oai:doaj.org-article:173b4cf1e5204bc1830a070b297e12c72021-11-18T08:12:23ZConcomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.1932-620310.1371/journal.pone.0046791https://doaj.org/article/173b4cf1e5204bc1830a070b297e12c72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071638/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In patients with temporal lobe epilepsy and associated hippocampal sclerosis (TLEhs) there are brain abnormalities extending beyond the presumed epileptogenic zone as revealed separately in conventional magnetic resonance imaging (MRI) and MR diffusion tensor imaging (DTI) studies. However, little is known about the relation between macroscopic atrophy (revealed by volumetric MRI) and microstructural degeneration (inferred by DTI).<h4>Methodology/principal findings</h4>For 62 patients with unilateral TLEhs and 68 healthy controls, we determined volumes and mean fractional anisotropy (FA) of ipsilateral and contralateral brain structures from T1-weighted and DTI data, respectively. We report significant volume atrophy and FA alterations of temporal lobe, subcortical and callosal regions, which were more diffuse and bilateral in patients with left TLEhs relative to right TLEhs. We observed significant relationships between volume loss and mean FA, particularly of the thalamus and putamen bilaterally. When corrected for age, duration of epilepsy was significantly correlated with FA loss of an anatomically plausible route - including ipsilateral parahippocampal gyrus and temporal lobe white matter, the thalamus bilaterally, and posterior regions of the corpus callosum that contain temporal lobe fibres - that may be suggestive of progressive brain degeneration in response to recurrent seizures.<h4>Conclusions/significance</h4>Chronic TLEhs is associated with interrelated DTI-derived and volume-derived brain degenerative abnormalities that are influenced by the duration of the disorder and the side of seizure onset. This work confirms previously contradictory findings by employing multi-modal imaging techniques in parallel in a large sample of patients.Simon S KellerJan-Christoph Schoene-BakeJan S GerdesBernd WeberMichael DeppePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e46791 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Simon S Keller
Jan-Christoph Schoene-Bake
Jan S Gerdes
Bernd Weber
Michael Deppe
Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
description <h4>Background</h4>In patients with temporal lobe epilepsy and associated hippocampal sclerosis (TLEhs) there are brain abnormalities extending beyond the presumed epileptogenic zone as revealed separately in conventional magnetic resonance imaging (MRI) and MR diffusion tensor imaging (DTI) studies. However, little is known about the relation between macroscopic atrophy (revealed by volumetric MRI) and microstructural degeneration (inferred by DTI).<h4>Methodology/principal findings</h4>For 62 patients with unilateral TLEhs and 68 healthy controls, we determined volumes and mean fractional anisotropy (FA) of ipsilateral and contralateral brain structures from T1-weighted and DTI data, respectively. We report significant volume atrophy and FA alterations of temporal lobe, subcortical and callosal regions, which were more diffuse and bilateral in patients with left TLEhs relative to right TLEhs. We observed significant relationships between volume loss and mean FA, particularly of the thalamus and putamen bilaterally. When corrected for age, duration of epilepsy was significantly correlated with FA loss of an anatomically plausible route - including ipsilateral parahippocampal gyrus and temporal lobe white matter, the thalamus bilaterally, and posterior regions of the corpus callosum that contain temporal lobe fibres - that may be suggestive of progressive brain degeneration in response to recurrent seizures.<h4>Conclusions/significance</h4>Chronic TLEhs is associated with interrelated DTI-derived and volume-derived brain degenerative abnormalities that are influenced by the duration of the disorder and the side of seizure onset. This work confirms previously contradictory findings by employing multi-modal imaging techniques in parallel in a large sample of patients.
format article
author Simon S Keller
Jan-Christoph Schoene-Bake
Jan S Gerdes
Bernd Weber
Michael Deppe
author_facet Simon S Keller
Jan-Christoph Schoene-Bake
Jan S Gerdes
Bernd Weber
Michael Deppe
author_sort Simon S Keller
title Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
title_short Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
title_full Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
title_fullStr Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
title_full_unstemmed Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
title_sort concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/173b4cf1e5204bc1830a070b297e12c7
work_keys_str_mv AT simonskeller concomitantfractionalanisotropyandvolumetricabnormalitiesintemporallobeepilepsycrosssectionalevidenceforprogressiveneurologicinjury
AT janchristophschoenebake concomitantfractionalanisotropyandvolumetricabnormalitiesintemporallobeepilepsycrosssectionalevidenceforprogressiveneurologicinjury
AT jansgerdes concomitantfractionalanisotropyandvolumetricabnormalitiesintemporallobeepilepsycrosssectionalevidenceforprogressiveneurologicinjury
AT berndweber concomitantfractionalanisotropyandvolumetricabnormalitiesintemporallobeepilepsycrosssectionalevidenceforprogressiveneurologicinjury
AT michaeldeppe concomitantfractionalanisotropyandvolumetricabnormalitiesintemporallobeepilepsycrosssectionalevidenceforprogressiveneurologicinjury
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