Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Zehra Edis,1,2,* Junli Wang,3,* Muhammad Khurram Waqas,4 Muhammad Ijaz,5 Munazza Ijaz6 1Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates; 2Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, U...

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Autores principales:	Edis Z, Wang J, Waqas MK, Ijaz M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nanomaterials anticancer agents recent advances multidrug resistance chemotherapy. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/173c81decfe04e4aa794519397c0f8fd
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spelling	oai:doaj.org-article:173c81decfe04e4aa794519397c0f8fd2021-12-02T14:20:03ZNanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives1178-2013https://doaj.org/article/173c81decfe04e4aa794519397c0f8fd2021-02-01T00:00:00Zhttps://www.dovepress.com/nanocarriers-mediated-drug-delivery-systems-for-anticancer-agents-an-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zehra Edis,1,2,* Junli Wang,3,* Muhammad Khurram Waqas,4 Muhammad Ijaz,5 Munazza Ijaz6 1Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates; 2Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates; 3Laboratory of Reproduction and Genetics, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, People’s Republic of China; 4Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan; 5Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan; 6Institute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore, Pakistan*These authors contributed equally to this workCorrespondence: Munazza IjazInstitute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore, 54000, PakistanEmail munazza3murtaza@gmail.comAbstract: Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for significant progress in the oncotherapy by enabling the delivery of chemotherapeutic agents at increased drug content levels to the targeted spots. Several nano-drug delivery systems designed for tumor-targeting are evaluated in preclinical and clinical trials and showed promising outcomes in cancerous tumors’ clinical management. This review describes nanocarrier’s importance in managing different types of cancers and emphasizing nanocarriers for drug delivery and cancer nanotherapeutics. It also highlights the recent advances in nanocarriers-based delivery systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid nanoparticles, and quantum dots (QDs). The nanocarrier-based composites are discussed in terms of their structure, characteristics, and therapeutic applications in oncology. To conclude, the challenges and future exploration opportunities of nanocarriers in chemotherapeutics are also presented.Keywords: nanomaterials, anticancer agents, recent advances, multidrug resistance, chemotherapyEdis ZWang JWaqas MKIjaz MIjaz MDove Medical Pressarticlenanomaterialsanticancer agentsrecent advancesmultidrug resistancechemotherapy.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1313-1330 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomaterials anticancer agents recent advances multidrug resistance chemotherapy. Medicine (General) R5-920
spellingShingle	nanomaterials anticancer agents recent advances multidrug resistance chemotherapy. Medicine (General) R5-920 Edis Z Wang J Waqas MK Ijaz M Ijaz M Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
description	Zehra Edis,1,2,* Junli Wang,3,* Muhammad Khurram Waqas,4 Muhammad Ijaz,5 Munazza Ijaz6 1Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates; 2Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates; 3Laboratory of Reproduction and Genetics, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, People’s Republic of China; 4Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan; 5Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan; 6Institute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore, Pakistan*These authors contributed equally to this workCorrespondence: Munazza IjazInstitute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore, 54000, PakistanEmail munazza3murtaza@gmail.comAbstract: Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for significant progress in the oncotherapy by enabling the delivery of chemotherapeutic agents at increased drug content levels to the targeted spots. Several nano-drug delivery systems designed for tumor-targeting are evaluated in preclinical and clinical trials and showed promising outcomes in cancerous tumors’ clinical management. This review describes nanocarrier’s importance in managing different types of cancers and emphasizing nanocarriers for drug delivery and cancer nanotherapeutics. It also highlights the recent advances in nanocarriers-based delivery systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid nanoparticles, and quantum dots (QDs). The nanocarrier-based composites are discussed in terms of their structure, characteristics, and therapeutic applications in oncology. To conclude, the challenges and future exploration opportunities of nanocarriers in chemotherapeutics are also presented.Keywords: nanomaterials, anticancer agents, recent advances, multidrug resistance, chemotherapy
format	article
author	Edis Z Wang J Waqas MK Ijaz M Ijaz M
author_facet	Edis Z Wang J Waqas MK Ijaz M Ijaz M
author_sort	Edis Z
title	Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
title_short	Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
title_full	Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
title_fullStr	Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
title_full_unstemmed	Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
title_sort	nanocarriers-mediated drug delivery systems for anticancer agents: an overview and perspectives
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/173c81decfe04e4aa794519397c0f8fd
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_version_	1718391532624543744

Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

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