New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27

In the course of screening new streptomycete strains, the strain <i>Streptomyces</i> sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structura...

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Autores principales:	Constanze Paulus, Oleksandr Gromyko, Andriy Luzhetskyy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyketide synthases <i>Streptomyces</i> ansamycins Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/173d9689da9542e2a5bc514edf0a85d1
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spelling	oai:doaj.org-article:173d9689da9542e2a5bc514edf0a85d12021-11-25T18:27:36ZNew Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-2710.3390/molecules262268341420-3049https://doaj.org/article/173d9689da9542e2a5bc514edf0a85d12021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6834https://doaj.org/toc/1420-3049In the course of screening new streptomycete strains, the strain <i>Streptomyces</i> sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of <i>Streptomyces</i> sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools.Constanze PaulusOleksandr GromykoAndriy LuzhetskyyMDPI AGarticlepolyketide synthases<i>Streptomyces</i>ansamycinsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6834, p 6834 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyketide synthases <i>Streptomyces</i> ansamycins Organic chemistry QD241-441
spellingShingle	polyketide synthases <i>Streptomyces</i> ansamycins Organic chemistry QD241-441 Constanze Paulus Oleksandr Gromyko Andriy Luzhetskyy New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
description	In the course of screening new streptomycete strains, the strain <i>Streptomyces</i> sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of <i>Streptomyces</i> sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools.
format	article
author	Constanze Paulus Oleksandr Gromyko Andriy Luzhetskyy
author_facet	Constanze Paulus Oleksandr Gromyko Andriy Luzhetskyy
author_sort	Constanze Paulus
title	New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
title_short	New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
title_full	New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
title_fullStr	New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
title_full_unstemmed	New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27
title_sort	new kendomycin derivative isolated from <i>streptomyces</i> sp. cl 58-27
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/173d9689da9542e2a5bc514edf0a85d1
work_keys_str_mv	AT constanzepaulus newkendomycinderivativeisolatedfromistreptomycesispcl5827 AT oleksandrgromyko newkendomycinderivativeisolatedfromistreptomycesispcl5827 AT andriyluzhetskyy newkendomycinderivativeisolatedfromistreptomycesispcl5827
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New Kendomycin Derivative Isolated from <i>Streptomyces</i> sp. Cl 58-27

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